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Zup1 zinc finger containing ubiquitin peptidase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294390, updated on 27-Nov-2024

Summary

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Official Symbol
Zup1provided by RGD
Official Full Name
zinc finger containing ubiquitin peptidase 1provided by RGD
Primary source
RGD:1307672
See related
EnsemblRapid:ENSRNOG00000000398 AllianceGenome:RGD:1307672
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
DUB; Zufsp; RGD1307672
Summary
Predicted to enable cysteine-type deubiquitinase activity and metal ion binding activity. Predicted to be located in cytosol and nucleoplasm. Orthologous to human ZUP1 (zinc finger containing ubiquitin peptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 168.8), Thymus (RPKM 140.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zup1 in Genome Data Viewer
Location:
20q11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (31327939..31358088, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (30785226..30815377, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (32471670..32501693, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 36, pseudogene 1 Neighboring gene radial spoke head component 4A Neighboring gene lysyl-tRNA synthetase 1, pseudogene 1 Neighboring gene karyopherin subunit alpha 5 Neighboring gene heat shock cognate 71 kDa protein pseudogene Neighboring gene uncharacterized LOC103694421

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC94667

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger-containing ubiquitin peptidase 1
Names
lys-63-specific deubiquitinase ZUFSP
ubiquitin carboxyl-terminal hydrolase ZUFSP
zinc finger with UFM1-specific peptidase domain protein
NP_001008309.1
XP_038954517.1
XP_038954518.1
XP_038954519.1
XP_038954520.1
XP_063135136.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008308.1 → NP_001008309.1  zinc finger-containing ubiquitin peptidase 1

    See identical proteins and their annotated locations for NP_001008309.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085885
    UniProtKB/Swiss-Prot
    Q5U2S3
    UniProtKB/TrEMBL
    A6K469, A6K470
    Related
    ENSRNOP00000000448.3, ENSRNOT00000000448.7
    Conserved Domains (1) summary
    pfam07910
    Location:335 → 550
    Peptidase_C78; Peptidase family C78

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    31327939..31358088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098589.2 → XP_038954517.1  zinc finger-containing ubiquitin peptidase 1 isoform X1

    Conserved Domains (1) summary
    pfam07910
    Location:140 → 355
    Peptidase_C78; Peptidase family C78

  2. XM_039098590.2 → XP_038954518.1  zinc finger-containing ubiquitin peptidase 1 isoform X2

    Conserved Domains (1) summary
    pfam07910
    Location:112 → 327
    Peptidase_C78; Peptidase family C78

  3. XM_039098592.2 → XP_038954520.1  zinc finger-containing ubiquitin peptidase 1 isoform X5

    Conserved Domains (1) summary
    pfam07910
    Location:54 → 269
    Peptidase_C78; Peptidase family C78

  4. XM_039098591.2 → XP_038954519.1  zinc finger-containing ubiquitin peptidase 1 isoform X3

  5. XM_063279066.1 → XP_063135136.1  zinc finger-containing ubiquitin peptidase 1 isoform X4

RNA

  1. XR_010060650.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2S3.1 GenPept UniProtKB/Swiss-Prot:Q5U2S3

Gene LinkOut

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