Slc26a4 solute carrier family 26 member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc26a4provided by RGD
Official Full Name: solute carrier family 26 member 4provided by RGD
Primary source: RGD:3293
See related: EnsemblRapid:ENSRNOG00000058692 AllianceGenome:RGD:3293
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pds
Summary: Enables chloride:bicarbonate antiporter activity and iodide transmembrane transporter activity. Involved in inorganic anion transport. Located in apical plasma membrane. Human ortholog(s) of this gene implicated in Pendred Syndrome; autosomal recessive nonsyndromic deafness 4; and goiter. Orthologous to human SLC26A4 (solute carrier family 26 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 152.1) and Kidney (RPKM 135.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (53835102..53873968, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (48107575..48153762, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (50809103..50848443, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pendrin abundance, subcellular distribution, and function are unaffected by either alphaENaC gene ablation or by increasing ENaC channel activity.
Title: Pendrin abundance, subcellular distribution, and function are unaffected by either αENaC gene ablation or by increasing ENaC channel activity.
Characterization of pendrin in urinary extracellular vesicles in a rat model of aldosterone excess and in human primary aldosteronism.
Title: Characterization of pendrin in urinary extracellular vesicles in a rat model of aldosterone excess and in human primary aldosteronism.
These studies implicate the involvement of pendrin-facilitated chloride-bicarbonate exchange in the regulation of airway surface liquid volume and suggest the utility of pendrin inhibitors in inflammatory lung diseases.
Title: Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis.
these data suggest that pendrin may have an important role in mediating iodide efflux in thyrocytes, especially under conditions of iodide excess.
Title: Iodide excess regulates its own efflux: a possible involvement of pendrin.
Pendrin is expressed in the adrenal medulla, where it blunts stress-induced catecholamine release.
Title: Pendrin localizes to the adrenal medulla and modulates catecholamine release.
Expression of slc26a4, slc26a6 and slc26a9 is increased in proximal tubule epithelial cells from spontaneously hypertensive rats compared with WKY control rats.
Title: Identification of SLC26A transporters involved in the Cl⁻/HCO₃⁻ exchange in proximal tubular cells from WKY and SHR.
Excessive mucus production, as implicated by significant overexpression of the pendrin coding gene, SLC26A4, was identified as a potential novel mechanism for silica-induced pulmonary toxicity.
Title: Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats.
These data show that intracellular iodide rapidly upregulates SLC26A4 mRNA expression.
Title: Iodide treatment acutely increases pendrin (SLC26A4) mRNA expression in the rat thyroid and the PCCl3 thyroid cell line by transcriptional mechanisms.
Bilateral ureteral obstruction caused a significant reduction in the expression of NHE3, NBC1, NKCC2, NBCn1, and pendrin.
Title: Ureter obstruction alters expression of renal acid-base transport proteins in rat kidney.
pendrin expression and localisation are regulated by insulin and influenced by a PKC-epsilon-dependent intracellular pathway.
Title: PKC-epsilon-dependent cytosol-to-membrane translocation of pendrin in rat thyroid PC Cl3 cells.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

RH129484 (e-PCR)
- UniSTS:212789

Slc26a4 (e-PCR), detects polymorphism
- UniSTS:527066

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride:bicarbonate antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info
enables iodide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables iodide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables secondary active sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in inorganic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in iodide transport	ISO Inferred from Sequence Orthology more info
involved_in oxalate transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pendrin

Names: Pendred syndrome homolog; sodium-independent chloride/iodide transporter; solute carrier family 26 (anion exchanger), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019214.1 → NP_062087.1 pendrin

See identical proteins and their annotated locations for NP_062087.1

Status: PROVISIONAL

Source sequence(s)

AF167412

UniProtKB/Swiss-Prot

Q9R154

UniProtKB/TrEMBL

A6HB50, A6HB51

Related

ENSRNOP00000070261.1, ENSRNOT00000087300.3

Conserved Domains (1) summary

TIGR00815
Location:70 → 725

sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

53835102..53873968 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594054.3 → XP_017449543.1 pendrin isoform X1

UniProtKB/Swiss-Prot

Q9R154

UniProtKB/TrEMBL

A6HB50, A6HB51

Conserved Domains (1) summary

TIGR00815
Location:70 → 725

sulP; high affinity sulphate transporter 1
XM_008764576.4 → XP_008762798.1 pendrin isoform X1

See identical proteins and their annotated locations for XP_008762798.1

UniProtKB/Swiss-Prot

Q9R154

UniProtKB/TrEMBL

A6HB50, A6HB51

Conserved Domains (1) summary

TIGR00815
Location:70 → 725

sulP; high affinity sulphate transporter 1
XM_008764577.4 → XP_008762799.1 pendrin isoform X2

UniProtKB/TrEMBL

A6HB50

Conserved Domains (2) summary

cd07042
Location:448 → 634

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

TIGR00815
Location:12 → 637

sulP; high affinity sulphate transporter 1