Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nus1provided by RGD
Official Full Name: NUS1 dehydrodolichyl diphosphate synthase subunitprovided by RGD
Primary source: RGD:1307879
See related: EnsemblRapid:ENSRNOG00000000411 AllianceGenome:RGD:1307879
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307879
Summary: Predicted to contribute to dehydrodolichyl diphosphate synthase activity. Predicted to be involved in several processes, including dolichol biosynthetic process; dolichyl diphosphate biosynthetic process; and positive regulation of nitric-oxide synthase activity. Predicted to act upstream of or within cholesterol homeostasis; protein mannosylation; and regulation of intracellular cholesterol transport. Predicted to be located in membrane. Predicted to be part of dehydrodolichyl diphosphate synthase complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 117.4), Adrenal (RPKM 102.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (32354519..32381265)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (31811817..31838562)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (33557052..33584011)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing Nogo-B improves the integrity of blood-retinal barrier in diabetic retinopathy via regulating Src, PI3K/Akt and ERK pathways.
Title: Silencing Nogo-B improves the integrity of blood-retinal barrier in diabetic retinopathy via regulating Src, PI3K/Akt and ERK pathways.
The results found that capillaries and vascular smooth muscle cell content reduced, and nogo-B receptor and ICAM-1 were elevated in rats with diabetic erectile dysfunction.
Title: Silencing Nogo-B receptor inhibits penile corpus cavernosum vascular smooth muscle cell apoptosis of rats with diabetic erectile dysfunction by down-regulating ICAM-1.
NUS1 was upregulated in IUAs tissues, and the high expression level of NUS1 was positively correlated with the severity of IUAs. NUS1 promoted cell proliferation in vitro. NUS1 overexpression on cell migration and invasion promoted the EMT process in vitro and in vivo.
Title: miR-466 and NUS1 Regulate the AKT/Nuclear Factor kappa B (NFκB) Signaling Pathway in Intrauterine Adhesions in a Rat Model.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130480 (e-PCR)
- UniSTS:213764

UniSTS:236351 (e-PCR)
- UniSTS:236351

RH130660 (e-PCR)
- UniSTS:213944

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to dehydrodolichyl diphosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dehydrodolichyl diphosphate synthase activity	ISO Inferred from Sequence Orthology more info
contributes_to prenyltransferase activity	ISO Inferred from Sequence Orthology more info
enables prenyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in dolichol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dolichol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dolichyl diphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein mannosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of intracellular cholesterol transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of dehydrodolichyl diphosphate synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dehydrodolichyl diphosphate synthase complex	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dehydrodolichyl diphosphate synthase complex subunit NUS1

Names: nogo-B receptor; nuclear undecaprenyl pyrophosphate synthase 1 homolog

NP_001157629.1

EC 2.5.1.87

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.