U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Glg1 golgi glycoprotein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29476, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Glg1provided by RGD
Official Full Name
golgi glycoprotein 1provided by RGD
Primary source
RGD:69345
See related
EnsemblRapid:ENSRNOG00000018668 AllianceGenome:RGD:69345
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Selel; MG-160
Summary
Enables fibroblast growth factor binding activity. Predicted to act upstream of or within several processes, including negative regulation of protein processing; negative regulation of transforming growth factor beta receptor signaling pathway; and regulation of chondrocyte differentiation. Located in Golgi medial cisterna. Orthologous to human GLG1 (golgi glycoprotein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 355.7), Kidney (RPKM 332.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Glg1 in Genome Data Viewer
Location:
19q12
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56034248..56133538, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39124892..39224178, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (42983879..43088074)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene essential MCU regulator, mitochondrial-like Neighboring gene ribosomal protein S20 like 6 Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit Neighboring gene ring finger and WD repeat domain 3 Neighboring gene U6 spliceosomal RNA Neighboring gene mixed lineage kinase domain like pseudokinase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. MG-160. A novel sialoglycoprotein of the medial cisternae of the Golgi apparatus [published eeratum appears in J Biol Chem 1989 Mar 5;264(7):4264]. Gonatas JO, et al. J Biol Chem, 1989 Jan 5. PMID 2909545
  2. Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis. Antoine M, et al. Oncol Rep, 2009 Feb. PMID 19148508
  3. MG-160, a membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus, binds basic fibroblast growth factor and exhibits a high level of sequence identity to a chicken fibroblast growth factor receptor. Gonatas JO, et al. J Cell Sci, 1995 Feb. PMID 7768993
  4. Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. Gruenheid S, et al. J Exp Med, 1997 Feb 17. PMID 9034150, Free PMC Article
  5. E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. Yang T, et al. J Clin Invest, 2010 Jul. PMID 20530870, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. under hypoxia, ESL-1 is shed from activated hepatic stellate cells
    Title: Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in bone morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bone morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of protein processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi medial cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Golgi apparatus protein 1
Names
E-selectin ligand 1
ESL-1
golgi sialoglycoprotein MG-160
selectin, endothelial cell, ligand

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017211.2 → NP_058907.1  Golgi apparatus protein 1 precursor

    See identical proteins and their annotated locations for NP_058907.1

    Status: PROVISIONAL

    Source sequence(s)
    U08136
    UniProtKB/Swiss-Prot
    Q62638
    UniProtKB/TrEMBL
    A6IZ85, G3V8G5
    Related
    ENSRNOP00000102342.1, ENSRNOT00000166511.1
    Conserved Domains (1) summary
    pfam00839
    Location:792 → 848
    Cys_rich_FGFR; Cysteine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    56034248..56133538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097676.2 → XP_038953604.1  Golgi apparatus protein 1 isoform X1

    UniProtKB/TrEMBL
    A6IZ85, G3V8G5
    Related
    ENSRNOP00000025570.2, ENSRNOT00000025570.5
    Conserved Domains (1) summary
    pfam00839
    Location:792 → 848
    Cys_rich_FGFR; Cysteine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62638.1 GenPept UniProtKB/Swiss-Prot:Q62638

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous