C1qtnf3 C1q and TNF related 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C1qtnf3provided by RGD
Official Full Name: C1q and TNF related 3provided by RGD
Primary source: RGD:1305010
See related: EnsemblRapid:ENSRNOG00000018570 AllianceGenome:RGD:1305010
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adim
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including intracellular triglyceride homeostasis; negative regulation of non-canonical NF-kappaB signal transduction; and regulation of cytokine production. Predicted to act upstream of or within glucose homeostasis; negative regulation of gluconeogenesis; and positive regulation of intracellular signal transduction. Predicted to be located in extracellular space. Predicted to be part of protein-containing complex. Orthologous to human C1QTNF3 (C1q and TNF related 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 241.7), Muscle (RPKM 43.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (61644225..61666640)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (59917099..59939519)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (60920160..60942586)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C1q/TNF-related protein 3 alleviates heart failure via attenuation of oxidative stress in myocardial infarction rats.
Title: C1q/TNF-related protein 3 alleviates heart failure via attenuation of oxidative stress in myocardial infarction rats.
CTRP3 protects against uric acid-induced endothelial injury by inhibiting inflammation and oxidase stress in rats.
Title: CTRP3 protects against uric acid-induced endothelial injury by inhibiting inflammation and oxidase stress in rats.
CTRP3 ameliorates fructose-induced metabolic associated fatty liver disease via inhibition of xanthine oxidase-associated oxidative stress.
Title: CTRP3 ameliorates fructose-induced metabolic associated fatty liver disease via inhibition of xanthine oxidase-associated oxidative stress.
CTRP3 protects the host against pathological cardiac remodeling and left ventricular dysfunction induced by pressure overload largely by inhibiting the p38/CREB pathway and alleviating p38-induced endoplasmic reticulum stress.
Title: C1q-TNF-related protein-3 attenuates pressure overload-induced cardiac hypertrophy by suppressing the p38/CREB pathway and p38-induced ER stress.
CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats
Title: CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats.
Results show that exogenous CTRP3 (lentivirus or recombinant CTRP3) in intracerebral hemorrhage (ICH) rats demonstrates the same tendency to attenuate ICH-induced brain injury, CTRP 3 inhibits oxidative stress and improves neural function during ICH via PKA signaling, and this information may have important therapeutic value for treating brain injury.
Title: C1q/tumor necrosis factor-related protein 3 inhibits oxidative stress during intracerebral hemorrhage via PKA signaling.
CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation
Title: CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation.
CTRP3 modulates mitochondrial energy production through targets of reactive oxygen species and proliferator-activated receptor-gamma coactivator-1alpha in vascular smooth muscle cells
Title: CTRP3 promotes energy production by inducing mitochondrial ROS and up-expression of PGC-1α in vascular smooth muscle cells.
Expression of CTRP3 in visceral adipose tissue was progressively decreased in a T2DM rat model from the pathogenic stage of IR to overt diabetes, while Ex-4 treatment increased its expression in such animals.
Title: Expression of CTRP3, a novel adipokine, in rats at different pathogenic stages of type 2 diabetes mellitus and the impacts of GLP-1 receptor agonist on it.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adiponectin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C1q tumor necrosis factor-related protein 3

Names: C1q and tumor necrosis factor related protein 3; adiponectin m

NP_001127908.1

EC 5.1.99.4

XP_006232129.3

EC 5.1.99.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134436.1 → NP_001127908.1 complement C1q tumor necrosis factor-related protein 3 precursor

See identical proteins and their annotated locations for NP_001127908.1

Status: PROVISIONAL

Source sequence(s)

BC162048

UniProtKB/TrEMBL

B1WC91

Related

ENSRNOP00000025170.5, ENSRNOT00000025170.7

Conserved Domains (3) summary

pfam00386
Location:192 → 315

C1q; C1q domain

pfam01391
Location:147 → 186

Collagen; Collagen triple helix repeat (20 copies)

NF038329
Location:100 → 188

gly_rich_SclB; LPXTG-anchored collagen-like adhesin Scl2/SclB

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

61644225..61666640

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232067.5 → XP_006232129.3 complement C1q tumor necrosis factor-related protein 3 isoform X1

Conserved Domains (2) summary

pfam00386
Location:119 → 242

C1q; C1q domain

pfam01391
Location:74 → 113

Collagen; Collagen triple helix repeat (20 copies)