Tpd52 tumor protein D52 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tpd52provided by RGD
Official Full Name: tumor protein D52provided by RGD
Primary source: RGD:1306767
See related: EnsemblRapid:ENSRNOG00000011441 AllianceGenome:RGD:1306767
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PrLZ; Crhsp-28
Summary: Predicted to enable calcium ion binding activity and protein homodimerization activity. Predicted to be involved in B cell differentiation and positive regulation of cell population proliferation. Predicted to be located in endoplasmic reticulum and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and glutamatergic synapse. Orthologous to human TPD52 (tumor protein D52). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 179.8), Brain (RPKM 154.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q23

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (94642514..94723442)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (92735365..92816079)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (94959732..95041277)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

binding of CRHSP-28 and annexin VI, together with their colocalization in the apical cytoplasm, is consistent with a role for these molecules in acinar cell membrane trafficking events that are essential for digestive enzyme secretion.
Title: Identification of annexin VI as a Ca2+-sensitive CRHSP-28-binding protein in pancreatic acinar cells.
data demonstrate that calcium-responsive heat stable protein-28(CRHSP-28 )phosphorylation occurs in vivo and can be used as a functional indicator of nutrient-driven pancreatic acinar cell activation
Title: Dietary and hormonal stimulation of rat exocrine pancreatic function regulates CRHSP-28 phosphorylation in vivo.
Calcium regulated heat stable protein-28 (CRHSP-28) accumulated on endosomes and positioned between zymogen granules below cell apex on CCK-8 stimulation. Present in acinar cells and regulated by secretagogue stimulation.
Title: Secretagogue-induced translocation of CRHSP-28 within an early apical endosomal compartment in acinar cells.
D52 regulates apical endolysosomal secretion in pancreatic acinar cells.
Title: Tumor protein D52 controls trafficking of an apical endolysosomal secretory pathway in pancreatic acinar cells.
Implicate both D52 expression and Ca(2+)-dependent phosphorylation at serine 136 in lysosomal membrane trafficking to and from the plasma membrane providing a novel Ca(2+)-sensitive pathway modulating the lysosome-like secretory pathway.
Title: Tumor protein D52 expression and Ca2+-dependent phosphorylation modulates lysosomal membrane protein trafficking to the plasma membrane.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor protein D52

Names: calcium regulated heat stable protein-28

XP_006232205.3

EC 2.7.1.21

XP_008759084.3

EC 2.7.1.21

XP_038957892.2

EC 2.7.1.21

XP_063137606.1

EC 2.7.1.21

XP_063137607.1

EC 2.7.1.21

XP_063137608.1

EC 2.7.1.21

XP_063137609.1

EC 2.7.1.21

XP_063137610.1

EC 2.7.1.21

XP_063137611.1

EC 2.7.1.21

XP_063137612.1

EC 2.7.1.21

XP_063137613.1

EC 2.7.1.21

XP_063137614.1

EC 2.7.1.21

XP_063137615.1

EC 2.7.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106421.3 → NP_001099891.3 tumor protein D52 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6IH66
NM_001401807.2 → NP_001388736.2 tumor protein D52 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

Related

ENSRNOP00000081198.2, ENSRNOT00000117383.2
NM_001401808.2 → NP_001388737.2 tumor protein D52 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002
NM_001429760.1 → NP_001416689.1 tumor protein D52 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002
NM_001429761.1 → NP_001416690.1 tumor protein D52 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002
NM_001429762.1 → NP_001416691.1 tumor protein D52 isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002
NM_001429763.1 → NP_001416692.1 tumor protein D52 isoform 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002
NM_001429764.1 → NP_001416693.1 tumor protein D52 isoform 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002
NM_001429765.1 → NP_001416694.1 tumor protein D52 isoform 9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002