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Mecom MDS1 and EVI1 complex locus [ Rattus norvegicus (Norway rat) ]

Gene ID: 294924, updated on 4-Jan-2025

Summary

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Symbol
Mecomprovided by RGD
Full Name
MDS1 and EVI1 complex locusprovided by RGD
Primary source
RGD:1310997
See related
EnsemblRapid:ENSRNOG00000012645 AllianceGenome:RGD:1310997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Evi1; Mds1
Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone H3K9 methyltransferase activity; and protein homodimerization activity. Predicted to be involved in several processes, including hematopoietic stem cell proliferation; negative regulation of JNK cascade; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; positive regulation of brown fat cell differentiation; and ureter morphogenesis. Predicted to be located in nuclear speck. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 186.7), Lung (RPKM 131.7) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mecom in Genome Data Viewer
Location:
2q24
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (114837815..115393052)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (112909353..113464583)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (117396084..117993604, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100572 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134485612 Neighboring gene EGF-like and EMI domain containing 1 Neighboring gene uncharacterized LOC134485895 Neighboring gene microRNA 551b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Suppression of Evi1 promotes the osteogenic differentiation and inhibits the adipogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro. An Q, et al. Int J Mol Med, 2015 Dec. PMID 26497332
  2. Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT. Liu Y, et al. Oncogene, 2006 Jun 15. PMID 16462766
  3. Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene. Matsugi T, et al. Mol Cell Biol, 1990 Mar. PMID 2106070, Free PMC Article
  4. Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders. Peeters P, et al. Cancer Res, 1997 Feb 15. PMID 9044825
  5. Zinc fingers 1-7 of EVI1 fail to bind to the GATA motif by itself but require the core site GACAAGATA for binding. Perkins AS, et al. J Biol Chem, 1996 Jan 12. PMID 8557637

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that the ectopic viral integration site1 (Evi1) gene may be targeted as a therapeutic strategy for promoting bone formation.
    Title: Suppression of Evi1 promotes the osteogenic differentiation and inhibits the adipogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro.
  2. Evi1 functions as a survival gene in intestinal epithelial cells and colon cancer cells
    Title: Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K9 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within forebrain development ISO
Inferred from Sequence Orthology
more info
  
involved_in hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in heterochromatin organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within maintenance of cell number ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neutrophil homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pericardium development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ureter morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase MECOM
Names
MDS1 and EVI1 complex locus protein EVI1
MDS1 and EVI1 complex locus protein MDS1
ecotropic viral integration site 1
myelodysplasia syndrome 1 homolog
NP_001376211.1
XP_006232311.1
XP_006232312.1
XP_038957898.1
XP_038957899.1
XP_038957900.1
XP_038957901.1
XP_038957902.1
XP_038957903.1
XP_038957904.1
XP_063137620.1
XP_063137621.1
XP_063137622.1
XP_063137623.1
XP_063137624.1
XP_063137625.1
XP_063137626.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389282.2 → NP_001376211.1  histone-lysine N-methyltransferase MECOM

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6GM83
    Related
    ENSRNOP00000097813.2, ENSRNOT00000107461.2
    Conserved Domains (6) summary
    PHA00733
    Location:881 → 977
    PHA00733; hypothetical protein
    COG5189
    Location:347 → 399
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:927 → 947
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl40432
    Location:50 → 207
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    pfam00096
    Location:925 → 947
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:939 → 963
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    114837815..115393052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101974.2 → XP_038957902.1  histone-lysine N-methyltransferase MECOM isoform X5

    UniProtKB/TrEMBL
    A0A8I6AF72
    Conserved Domains (6) summary
    PHA00733
    Location:881 → 977
    PHA00733; hypothetical protein
    COG5189
    Location:305 → 399
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:927 → 947
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl40432
    Location:50 → 207
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    pfam00096
    Location:925 → 947
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:939 → 963
    zf-H2C2_2; Zinc-finger double domain

  2. XM_039101971.2 → XP_038957899.1  histone-lysine N-methyltransferase MECOM isoform X2

    UniProtKB/TrEMBL
    A0A8I6ASQ3, A0A8I6GM83
    Conserved Domains (6) summary
    PHA00733
    Location:849 → 968
    PHA00733; hypothetical protein
    COG5189
    Location:347 → 399
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:918 → 938
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl40432
    Location:50 → 207
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    pfam00096
    Location:916 → 938
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:930 → 954
    zf-H2C2_2; Zinc-finger double domain

  3. XM_063281551.1 → XP_063137621.1  histone-lysine N-methyltransferase MECOM isoform X7

    UniProtKB/TrEMBL
    A0A8I6AF72

  4. XM_039101975.2 → XP_038957903.1  histone-lysine N-methyltransferase MECOM isoform X11

    UniProtKB/TrEMBL
    A0A8I6AT27
    Conserved Domains (6) summary
    COG5048
    Location:292 → 644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:603 → 623
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl40432
    Location:50 → 207
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    pfam00096
    Location:601 → 623
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:615 → 639
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:268 → 314
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  5. XM_063281555.1 → XP_063137625.1  histone-lysine N-methyltransferase MECOM isoform X15

    UniProtKB/TrEMBL
    A0A8I6AT27

  6. XM_063281554.1 → XP_063137624.1  histone-lysine N-methyltransferase MECOM isoform X13

    UniProtKB/TrEMBL
    A0A8I6AT27

  7. XM_039101970.2 → XP_038957898.1  histone-lysine N-methyltransferase MECOM isoform X1

    UniProtKB/TrEMBL
    A0A8I6GM83
    Related
    ENSRNOP00000109883.1, ENSRNOT00000139439.1
    Conserved Domains (6) summary
    PHA00733
    Location:880 → 976
    PHA00733; hypothetical protein
    COG5189
    Location:305 → 398
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:926 → 946
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl40432
    Location:50 → 207
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    pfam00096
    Location:924 → 946
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:938 → 962
    zf-H2C2_2; Zinc-finger double domain

  8. XM_063281550.1 → XP_063137620.1  histone-lysine N-methyltransferase MECOM isoform X6

    UniProtKB/TrEMBL
    A0A8I6AF72

  9. XM_039101972.2 → XP_038957900.1  histone-lysine N-methyltransferase MECOM isoform X3

    UniProtKB/TrEMBL
    A0A8I6GM83
    Related
    ENSRNOP00000107002.1, ENSRNOT00000158911.1
    Conserved Domains (6) summary
    PHA00733
    Location:848 → 967
    PHA00733; hypothetical protein
    COG5189
    Location:305 → 398
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:917 → 937
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl40432
    Location:50 → 207
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    pfam00096
    Location:915 → 937
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:929 → 953
    zf-H2C2_2; Zinc-finger double domain

  10. XM_063281552.1 → XP_063137622.1  histone-lysine N-methyltransferase MECOM isoform X8

    UniProtKB/TrEMBL
    A0A8I6AF72
    Related
    ENSRNOP00000095014.2, ENSRNOT00000099354.2

  11. XM_063281553.1 → XP_063137623.1  histone-lysine N-methyltransferase MECOM isoform X12

    UniProtKB/TrEMBL
    A0A8I6AT27

  12. XM_039101976.2 → XP_038957904.1  histone-lysine N-methyltransferase MECOM isoform X14

    UniProtKB/TrEMBL
    A0A8I6AT27
    Related
    ENSRNOP00000095216.1, ENSRNOT00000102002.2

  13. XM_063281556.1 → XP_063137626.1  histone-lysine N-methyltransferase MECOM isoform X16

    UniProtKB/TrEMBL
    A0A8I6AT27

  14. XM_039101973.2 → XP_038957901.1  histone-lysine N-methyltransferase MECOM isoform X4

    UniProtKB/TrEMBL
    A0A8I6GM83
    Conserved Domains (6) summary
    PHA00733
    Location:870 → 966
    PHA00733; hypothetical protein
    COG5189
    Location:336 → 388
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:916 → 936
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl40432
    Location:39 → 196
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    pfam00096
    Location:914 → 936
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:928 → 952
    zf-H2C2_2; Zinc-finger double domain

  15. XM_006232250.5 → XP_006232312.1  histone-lysine N-methyltransferase MECOM isoform X10

    UniProtKB/TrEMBL
    A0A8I6GM83
    Related
    ENSRNOP00000091427.2, ENSRNOT00000095020.2
    Conserved Domains (4) summary
    sd00017
    Location:736 → 756
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:734 → 756
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:748 → 772
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:164 → 245
    zf-C2H2_8; C2H2-type zinc ribbon

  16. XM_006232249.5 → XP_006232311.1  histone-lysine N-methyltransferase MECOM isoform X9

    UniProtKB/TrEMBL
    A0A8I6GM83
    Conserved Domains (5) summary
    smart00317
    Location:7 → 68
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:800 → 820
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:798 → 820
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:812 → 836
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:228 → 309
    zf-C2H2_8; C2H2-type zinc ribbon

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106423.1: Suppressed sequence

    Description
    NM_001106423.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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