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Ints12 integrator complex subunit 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295448, updated on 9-Dec-2024

Summary

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Official Symbol
Ints12provided by RGD
Official Full Name
integrator complex subunit 12provided by RGD
Primary source
RGD:1359136
See related
EnsemblRapid:ENSRNOG00000011844 AllianceGenome:RGD:1359136
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Phf22
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Orthologous to human INTS12 (integrator complex subunit 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Heart (RPKM 53.7), Thymus (RPKM 51.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ints12 in Genome Data Viewer
Location:
2q43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (224265787..224283523)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (221591761..221609497)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (238253114..238270722)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene nephronectin Neighboring gene MTOR associated protein, eak-7 homolog, pseudogene 1 Neighboring gene uncharacterized LOC102548236 Neighboring gene glutathione S-transferase, C-terminal domain containing Neighboring gene Rho guanine nucleotide exchange factor 38 Neighboring gene uncharacterized LOC102546359 Neighboring gene inorganic pyrophosphatase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
  2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94937

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex IEA
Inferred from Electronic Annotation
more info
  
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
integrator complex subunit 12
Names
PHD finger protein 22
int12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007640.2 → NP_001007641.1  integrator complex subunit 12

    See identical proteins and their annotated locations for NP_001007641.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q68FR3
    UniProtKB/TrEMBL
    A6HVU5
    Related
    ENSRNOP00000016066.5, ENSRNOT00000016066.8
    Conserved Domains (1) summary
    cd15501
    Location:160 → 211
    PHD_Int12; PHD finger found in integrator complex subunit 12 (Int12) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    224265787..224283523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233320.5 → XP_006233382.1  integrator complex subunit 12 isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHJ4
    Related
    ENSRNOP00000088831.1, ENSRNOT00000116296.2
    Conserved Domains (1) summary
    cd15501
    Location:166 → 217
    PHD_Int12; PHD finger found in integrator complex subunit 12 (Int12) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FR3.1 GenPept UniProtKB/Swiss-Prot:Q68FR3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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