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Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295549, updated on 2-Nov-2024

Summary

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Official Symbol
Dnajb4provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member B4provided by RGD
Primary source
RGD:1305826
See related
EnsemblRapid:ENSRNOG00000013011 AllianceGenome:RGD:1305826
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATPase activator activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding and negative regulation of transcription by RNA polymerase II. Predicted to be located in Z disc; nucleoplasm; and plasma membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital myopathy 21. Orthologous to human DNAJB4 (DnaJ heat shock protein family (Hsp40) member B4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 256.4), Heart (RPKM 179.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnajb4 in Genome Data Viewer
Location:
2q45
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (243790296..243819042, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241129346..241159272, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257394692..257425344, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548701 Neighboring gene 40S ribosomal protein S10 pseudogene Neighboring gene GIPC PDZ domain containing family, member 2 Neighboring gene far upstream element binding protein 1 Neighboring gene transmembrane protein 256, pseudogene 2 Neighboring gene nexilin (F actin binding protein)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. Rauch JN, et al. J Biol Chem, 2014 Jan 17. PMID 24318877, Free PMC Article
  2. Mapping the in vitro interactome of cardiac sodium (Na(+) )-calcium (Ca(2+) ) exchanger 1 (NCX1). Lubelwana Hafver T, et al. Proteomics, 2017 Sep. PMID 28755400
  3. The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. Hageman J, et al. Biochem J, 2011 Apr 1. PMID 21231916
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily B member 4
Names
DnaJ (Hsp40) homolog, subfamily B, member 4
DnaJ (Hsp40) homolog, subfamily B, member 4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013076.1 → NP_001013094.1  dnaJ homolog subfamily B member 4

    See identical proteins and their annotated locations for NP_001013094.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083638
    UniProtKB/TrEMBL
    A0A9K3Y755, F1LNN0, Q5XIP0
    Related
    ENSRNOP00000017381.6, ENSRNOT00000017381.8
    Conserved Domains (3) summary
    cd10747
    Location:158 → 320
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:1 → 332
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:4 → 65
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    243790296..243819042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233488.3 → XP_006233550.1  dnaJ homolog subfamily B member 4 isoform X1

    See identical proteins and their annotated locations for XP_006233550.1

    UniProtKB/TrEMBL
    A0A9K3Y755, F1LNN0, Q5XIP0
    Conserved Domains (3) summary
    cd10747
    Location:158 → 320
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:1 → 332
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:4 → 65
    DnaJ; DnaJ domain
Nucleotide Protein Strain
Heading Accession and Version

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