Ube2l6 ubiquitin-conjugating enzyme E2L 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ube2l6provided by RGD
Official Full Name: ubiquitin-conjugating enzyme E2L 6provided by RGD
Primary source: RGD:1307960
See related: EnsemblRapid:ENSRNOG00000030467 AllianceGenome:RGD:1307960
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ISG15 transferase activity; ubiquitin binding activity; and ubiquitin conjugating enzyme activity. Predicted to be involved in innate immune response; protein modification by small protein conjugation; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within modification-dependent protein catabolic process. Predicted to be active in nucleus. Orthologous to human UBE2L6 (ubiquitin conjugating enzyme E2 L6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 83.5), Lung (RPKM 49.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (90279705..90294721)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (69873025..69888042)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (72191533..72206190)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ISG15 transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ISG15 transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ISG15-protein conjugation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ISG15-protein conjugation	ISO Inferred from Sequence Orthology more info
involved_in ISG15-protein conjugation	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within modification-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin/ISG15-conjugating enzyme E2 L6

Names: E2 ubiquitin-conjugating enzyme L6; ubcM8; ubiquitin carrier protein L6; ubiquitin-protein ligase L6

NP_001019926.1

EC 2.3.2.23

XP_017447037.1

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024755.1 → NP_001019926.1 ubiquitin/ISG15-conjugating enzyme E2 L6

See identical proteins and their annotated locations for NP_001019926.1

Status: PROVISIONAL

Source sequence(s)

BC097364

UniProtKB/Swiss-Prot

Q4V8J2

UniProtKB/TrEMBL

A0A8L2QJE0, A6HMR6

Related

ENSRNOP00000095336.2, ENSRNOT00000106051.2

Conserved Domains (2) summary

COG5078
Location:1 → 147

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

pfam00179
Location:6 → 144

UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

90279705..90294721

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591548.3 → XP_017447037.1 ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1

Conserved Domains (1) summary

pfam00179
Location:5 → 108

UQ_con; Ubiquitin-conjugating enzyme