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Gjb3 gap junction protein, beta 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29585, updated on 27-Nov-2024

Summary

Official Symbol
Gjb3provided by RGD
Official Full Name
gap junction protein, beta 3provided by RGD
Primary source
RGD:2695
See related
EnsemblRapid:ENSRNOG00000014372 AllianceGenome:RGD:2695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cxnc
Summary
Predicted to enable gap junction channel activity. Involved in several processes, including cellular response to retinoic acid; in utero embryonic development; and spermatogenesis. Located in gap junction. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 2B; autosomal recessive nonsyndromic deafness 1A; colorectal adenocarcinoma; erythrokeratodermia variabilis; and erythrokeratodermia variabilis et progressiva 1. Orthologous to human GJB3 (gap junction protein beta 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 6.6), Testes (RPKM 4.2) and 7 other tissues See more
Orthologs
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Genomic context

See Gjb3 in Genome Data Viewer
Location:
5q36
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (144933692..144939435, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (139649227..139654970, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (145390590..145397271, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 260 Neighboring gene gap junction protein, alpha 4 Neighboring gene gap junction protein, beta 4 Neighboring gene gap junction protein, beta 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables gap junction channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in in utero embryonic development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
 
involved_in skin development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
part_of connexin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in gap junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in gap junction ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gap junction beta-3 protein
Names
connexin c
connexin-31
cx31
gap junction membrane channel protein beta 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411660.1NP_001398589.1  gap junction beta-3 protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P25305
    UniProtKB/TrEMBL
    A0A654ICZ5
    Related
    ENSRNOP00000019266.1, ENSRNOT00000019266.4
  2. NM_019240.2NP_062113.1  gap junction beta-3 protein

    See identical proteins and their annotated locations for NP_062113.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P25305
    UniProtKB/TrEMBL
    A0A654ICZ5
    Related
    ENSRNOP00000098696.1, ENSRNOT00000172004.1
    Conserved Domains (1) summary
    pfam00029
    Location:2211
    Connexin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    144933692..144939435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)