Pou3f2 POU class 3 homeobox 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pou3f2provided by RGD
Official Full Name: POU class 3 homeobox 2provided by RGD
Primary source: RGD:61946
See related: EnsemblRapid:ENSRNOG00000063836 AllianceGenome:RGD:61946
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Brn-2; OTF-7; oct-7
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and sequence-specific DNA binding activity. Involved in regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of transcription regulator complex. Orthologous to human POU3F2 (POU class 3 homeobox 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: 5q21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (40874631..40880539, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (36077930..36083838, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (36677452..36683356, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:492577 (e-PCR)
- UniSTS:492577

Pou3f2 (e-PCR), detects polymorphism
- UniSTS:144243

PMC196070P1 (e-PCR)
- UniSTS:271795

PMC317216P1 (e-PCR)
- UniSTS:273079

Pou3f2 (e-PCR), detects polymorphism
- UniSTS:547294

Pou3f2 (e-PCR), detects polymorphism
- UniSTS:536545

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables HMG box domain binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Schwann cell development	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex radially oriented cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex radially oriented cell migration	ISO Inferred from Sequence Orthology more info
involved_in epidermis development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epidermis development	ISO Inferred from Sequence Orthology more info
involved_in forebrain astrocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within forebrain astrocyte development	ISO Inferred from Sequence Orthology more info
involved_in forebrain ventricular zone progenitor cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within forebrain ventricular zone progenitor cell division	ISO Inferred from Sequence Orthology more info
involved_in hypothalamus cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hypothalamus cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in myelination in peripheral nervous system	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myelination in peripheral nervous system	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuroendocrine cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuroendocrine cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in neurohypophysis development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurohypophysis development	ISO Inferred from Sequence Orthology more info
involved_in neuron development	IEA Inferred from Electronic Annotation more info
involved_in neuron development	ISO Inferred from Sequence Orthology more info
involved_in neuron development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron fate commitment	ISO Inferred from Sequence Orthology more info
involved_in neuron fate commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron fate specification	IEA Inferred from Electronic Annotation more info
involved_in neuron fate specification	ISO Inferred from Sequence Orthology more info
involved_in neuron fate specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of axonogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: POU domain, class 3, transcription factor 2

Names: brain-2; brain-specific homeobox/POU domain protein 2; nervous system-specific octamer-binding transcription factor N-Oct-3; octamer-binding protein 7; octamer-binding transcription factor 7; protein Brn-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172085.4 → NP_742082.2 POU domain, class 3, transcription factor 2

See identical proteins and their annotated locations for NP_742082.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P56222

UniProtKB/TrEMBL

A6IIG2, G3V6U5

Related

ENSRNOP00000078344.1, ENSRNOT00000120257.2

Conserved Domains (2) summary

smart00352
Location:264 → 338

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:359 → 412

Homeobox; Homeobox domain