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Commd9 COMM domain containing 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295956, updated on 27-Nov-2024

Summary

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Official Symbol
Commd9provided by RGD
Official Full Name
COMM domain containing 9provided by RGD
Primary source
RGD:1307706
See related
EnsemblRapid:ENSRNOG00000004755 AllianceGenome:RGD:1307706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to act upstream of or within cholesterol homeostasis. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Orthologous to human COMMD9 (COMM domain containing 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 291.0), Lung (RPKM 196.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Commd9 in Genome Data Viewer
Location:
3q31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (108630903..108645427)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (88175909..88190427)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (91463612..91478097)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 6 Neighboring gene proline rich 5 like Neighboring gene uncharacterized LOC134486413 Neighboring gene low density lipoprotein receptor class A domain containing 3 Neighboring gene uncharacterized LOC120101606

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel. Liu YF, et al. Am J Physiol Renal Physiol, 2013 Jul 1. PMID 23637203
  2. Functional identification of neuroprotective molecules. Dai C, et al. PLoS One, 2010 Nov 24. PMID 21124846, Free PMC Article
  3. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Bartuzi P, et al. Nat Commun, 2016 Mar 11. PMID 26965651, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124765

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
COMM domain-containing protein 9
Names
neuroprotective protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033692.2 → NP_001028864.1  COMM domain-containing protein 9 isoform 1

    See identical proteins and their annotated locations for NP_001028864.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    B3SVE6, F7F1B8, Q3MIE7
    Related
    ENSRNOP00000101505.1, ENSRNOT00000147312.1
    Conserved Domains (2) summary
    cd04757
    Location:90 → 197
    Commd9; COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
    pfam03081
    Location:10 → 146
    Exo70; Exo70 exocyst complex subunit

  2. NM_001429952.1 → NP_001416881.1  COMM domain-containing protein 9 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNM9

  3. NM_001429953.1 → NP_001416882.1  COMM domain-containing protein 9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    F7F1B8, Q3MIE7

  4. NM_001429954.1 → NP_001416883.1  COMM domain-containing protein 9 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNM9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    108630903..108645427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234637.5 → XP_006234699.1  COMM domain-containing protein 9 isoform X1

    Related
    ENSRNOP00000070509.3, ENSRNOT00000081984.3
    Conserved Domains (2) summary
    cd04757
    Location:90 → 197
    Commd9; COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
    pfam03081
    Location:10 → 146
    Exo70; Exo70 exocyst complex subunit

  2. XM_063283308.1 → XP_063139378.1  COMM domain-containing protein 9 isoform X4

  3. XM_039104527.1 → XP_038960455.1  COMM domain-containing protein 9 isoform X2

    Conserved Domains (1) summary
    cd04757
    Location:48 → 155
    Commd9; COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

  4. XM_063283307.1 → XP_063139377.1  COMM domain-containing protein 9 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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