Ifrd1 interferon-related developmental regulator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ifrd1provided by RGD
Full Name: interferon-related developmental regulator 1provided by RGD
Primary source: RGD:2867
See related: EnsemblRapid:ENSRNOG00000050997 AllianceGenome:RGD:2867
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pc4
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in glial cell proliferation and neuroblast proliferation. Acts upstream of or within positive regulation of DNA-binding transcription factor activity and positive regulation of transcription by RNA polymerase II. Predicted to be located in sarcoplasm. Predicted to be active in nucleus. Orthologous to human IFRD1 (interferon related developmental regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 139.6), Liver (RPKM 118.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q21

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (62996560..63044996, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (57269395..57317833, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (60132025..60151354, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings thus suggest that the stimulation of Errfi1 and Ifrd1 may be important for theca and granulosa cell differentiation and oocyte complexes expansion.
Title: Expression and regulation of the differentiation regulators ERBB Receptor Feedback Inhibitor 1 (ERRFI1) and Interferon-related Developmental Regulator 1 (IFRD1) during the periovulatory period in the rat ovary.
PC4 acts as a coactivator of MyoD and MEF2C by removing the inhibitory effect of HDAC4, thus exerting a pivotal function during myogenesis.
Title: PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C.
PC4 is a regulator of transcription involved in tissue regeneration after ischemic stroke.
Title: Temporal and spatial gene expression patterns after experimental stroke in a rat model and characterization of PC4, a potential regulator of transcription.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in glial cell proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in muscle cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in muscle cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of axon extension	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collateral sprouting	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in neuroblast proliferation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in skeletal muscle tissue regeneration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
involved_in striated muscle tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within striated muscle tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasm	IEA Inferred from Electronic Annotation more info
located_in sarcoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon-related developmental regulator 1

Names: IRPR; nerve growth factor-inducible protein PC4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019242.2 → NP_062115.2 interferon-related developmental regulator 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

P20695

UniProtKB/TrEMBL

M0RDM5, Q5XIV9

Related

ENSRNOP00000067730.1, ENSRNOT00000073910.3

Conserved Domains (2) summary

pfam04836
Location:390 → 443

IFRD_C; Interferon-related protein conserved region

pfam05004
Location:40 → 345

IFRD; Interferon-related developmental regulator (IFRD)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

62996560..63044996 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111855.2 → XP_038967783.1 interferon-related developmental regulator 1 isoform X2

UniProtKB/TrEMBL

A0A8I6ACL6

Related

ENSRNOP00000089876.1, ENSRNOT00000109955.2

Conserved Domains (2) summary

pfam04836
Location:342 → 395

IFRD_C; Interferon-related protein conserved region

pfam05004
Location:1 → 297

IFRD; Interferon-related developmental regulator (IFRD)
XM_039111854.2 → XP_038967782.1 interferon-related developmental regulator 1 isoform X1

UniProtKB/Swiss-Prot

P20695

Conserved Domains (2) summary

pfam04836
Location:345 → 398

IFRD_C; Interferon-related protein conserved region

pfam05004
Location:40 → 319

IFRD; Interferon-related developmental regulator (IFRD)