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Depdc7 DEP domain containing 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295971, updated on 4-Jan-2025

Summary

Official Symbol
Depdc7provided by RGD
Official Full Name
DEP domain containing 7provided by RGD
Primary source
RGD:1309720
See related
EnsemblRapid:ENSRNOG00000012262 AllianceGenome:RGD:1309720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309720
Summary
Predicted to be involved in intracellular signal transduction. Orthologous to human DEPDC7 (DEP domain containing 7). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 650.3), Kidney (RPKM 184.4) and 1 other tissue See more
Orthologs
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Genomic context

See Depdc7 in Genome Data Viewer
Location:
3q32
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (111554701..111575979, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (91099111..91121152, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (94665714..94687013, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cleavage stimulation factor subunit 3 Neighboring gene t-complex 11 like 1 Neighboring gene uncharacterized LOC134486132 Neighboring gene glutamine and serine rich 1 Neighboring gene proline rich and Gla domain 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General protein information

Preferred Names
DEP domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029916.1NP_001025087.1  DEP domain-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001025087.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097357
    UniProtKB/Swiss-Prot
    Q4QR86
    UniProtKB/TrEMBL
    A6HNU9
    Related
    ENSRNOP00000016677.5, ENSRNOT00000016677.7
    Conserved Domains (2) summary
    cd04405
    Location:192425
    RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...
    cd04446
    Location:39133
    DEP_DEPDC4; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.
  2. NM_001429957.1NP_001416886.1  DEP domain-containing protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZY15

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    111554701..111575979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104531.2XP_038960459.1  DEP domain-containing protein 7 isoform X1

    Related
    ENSRNOP00000082907.1, ENSRNOT00000111299.2
    Conserved Domains (2) summary
    cd04405
    Location:179412
    RhoGAP_BRCC3-like; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal ...
    cd04446
    Location:26120
    DEP_DEPDC4; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.