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Mettl15 methyltransferase 15, mitochondrial 12S rRNA N4-cytidine [ Rattus norvegicus (Norway rat) ]

Gene ID: 295985, updated on 4-Jan-2025

Summary

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Official Symbol
Mettl15provided by RGD
Official Full Name
methyltransferase 15, mitochondrial 12S rRNA N4-cytidineprovided by RGD
Primary source
RGD:1304978
See related
EnsemblRapid:ENSRNOG00000066683 AllianceGenome:RGD:1304978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304978
Summary
Predicted to enable rRNA (cytosine-N4-)-methyltransferase activity. Predicted to be involved in rRNA base methylation. Predicted to be active in mitochondrial matrix. Orthologous to several human genes including METTL15 (methyltransferase 15, mitochondrial 12S rRNA N4-cytidine). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 25.1), Heart (RPKM 23.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mettl15 in Genome Data Viewer
Location:
3q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (116041480..116219011, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (95586855..95764392, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (100186106..100366148, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7, pseudogene 2 Neighboring gene ribosomal protein S6, pseudogene 12 Neighboring gene growth factor receptor bound protein 7, pseudogene 1 Neighboring gene kinesin family member 18A Neighboring gene transfer RNA alanine (anticodon GGC) 3 Neighboring gene adenosylhomocysteinase, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108934

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables rRNA (cytosine-N4-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (cytosine-N4-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA base methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
12S rRNA N4-methylcytidine (m4C) methyltransferase
Names
methyltransferase like 15
probable methyltransferase-like protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024981.2 → NP_001020152.2  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  2. NM_001431510.1 → NP_001418439.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNZ7, F7F172

  3. NM_001431511.1 → NP_001418440.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNZ7, F7F172

  4. NM_001431512.1 → NP_001418441.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNZ7, F7F172

  5. NM_001431513.1 → NP_001418442.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNZ7, F7F172

  6. NM_001431514.1 → NP_001418443.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    116041480..116219011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234687.5 → XP_006234749.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

    Conserved Domains (1) summary
    PRK00050
    Location:72 → 406
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

  2. XM_008762086.3 → XP_008760308.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_008760308.1

    UniProtKB/TrEMBL
    A6HNZ7, F7F172
    Related
    ENSRNOP00000091130.1, ENSRNOT00000098239.2
    Conserved Domains (1) summary
    PRK00050
    Location:72 → 406
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

  3. XM_017591566.3 → XP_017447055.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

    Conserved Domains (1) summary
    PRK00050
    Location:72 → 406
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

  4. XM_006234689.5 → XP_006234751.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006234751.1

    UniProtKB/TrEMBL
    A6HNZ7, F7F172
    Conserved Domains (1) summary
    PRK00050
    Location:72 → 406
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

  5. XM_008762085.4 → XP_008760307.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_008760307.1

    UniProtKB/TrEMBL
    A6HNZ7, F7F172
    Conserved Domains (1) summary
    PRK00050
    Location:72 → 406
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

  6. XM_008762084.4 → XP_008760306.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

    Conserved Domains (1) summary
    PRK00050
    Location:72 → 406
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

  7. XM_006234688.5 → XP_006234750.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006234750.1

    UniProtKB/TrEMBL
    A6HNZ7, F7F172
    Conserved Domains (1) summary
    PRK00050
    Location:72 → 406
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

  8. XM_006234686.5 → XP_006234748.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

    Conserved Domains (1) summary
    PRK00050
    Location:72 → 406
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

  9. XM_017591567.3 → XP_017447056.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

    UniProtKB/TrEMBL
    A6HNZ7, F7F172
    Conserved Domains (1) summary
    PRK00050
    Location:72 → 406
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

  10. XM_063283310.1 → XP_063139380.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X2

  11. XM_063283309.1 → XP_063139379.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X2

  12. XM_063283311.1 → XP_063139381.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X3

  13. XM_063283312.1 → XP_063139382.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X4

RNA

  1. XR_010064579.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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