Bckdk branched chain ketoacid dehydrogenase kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bckdkprovided by RGD
Official Full Name: branched chain ketoacid dehydrogenase kinaseprovided by RGD
Primary source: RGD:2198
See related: EnsemblRapid:ENSRNOG00000077965 AllianceGenome:RGD:2198
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BDK
Summary: Enables ATP binding activity and [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity. Involved in branched-chain amino acid catabolic process; phosphorylation; and spermatogenesis. Part of oxoglutarate dehydrogenase complex. Used to study branched-chain keto acid dehydrogenase kinase deficiency and oligospermia. Human ortholog(s) of this gene implicated in branched-chain keto acid dehydrogenase kinase deficiency. Orthologous to human BCKDK (branched chain keto acid dehydrogenase kinase). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Muscle (RPKM 490.3), Heart (RPKM 459.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191945809..191950480)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182515335..182520007)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (199351628..199356299)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bckdk (e-PCR), detects polymorphism
- UniSTS:141162

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity	TAS Traceable Author Statement more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein propionyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-leucine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branched-chain amino acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in branched-chain amino acid catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dosage compensation by inactivation of X chromosome	IEA Inferred from Electronic Annotation more info
involved_in isoleucine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of skeletal muscle satellite cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription initiation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in post-embryonic hemopoiesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial transcription	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in valine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MLL1 complex	IEA Inferred from Electronic Annotation more info
part_of MSL complex	IEA Inferred from Electronic Annotation more info
part_of NSL complex	IEA Inferred from Electronic Annotation more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of oxoglutarate dehydrogenase complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: branched-chain alpha-ketoacid dehydrogenase kinase

Names: BCKD-kinase; BCKDH kinase; BCKDHKIN; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

NP_062117.2

EC 2.7.11.1

EC 2.7.11.4

XP_063143730.1

EC 2.7.11.1

EC 2.7.11.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019244.2 → NP_062117.2 branched-chain alpha-ketoacid dehydrogenase kinase precursor

See identical proteins and their annotated locations for NP_062117.2

Status: VALIDATED

Source sequence(s)

BM392152, CK479351, U27456

UniProtKB/Swiss-Prot

Q00972, Q64552

UniProtKB/TrEMBL

A6I9W3

Conserved Domains (2) summary

cd16929
Location:226 → 401

HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains

pfam10436
Location:69 → 222

BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase