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Emc7 ER membrane protein complex subunit 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296050, updated on 4-Jan-2025

Summary

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Official Symbol
Emc7provided by RGD
Official Full Name
ER membrane protein complex subunit 7provided by RGD
Primary source
RGD:1305045
See related
EnsemblRapid:ENSRNOG00000005884 AllianceGenome:RGD:1305045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305045
Summary
Predicted to enable carbohydrate binding activity. Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of EMC complex. Orthologous to human EMC7 (ER membrane protein complex subunit 7). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 489.0), Kidney (RPKM 428.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Emc7 in Genome Data Viewer
Location:
3q35
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (119714617..119728748)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (99263933..99274365)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (103945276..103955970)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 6 Neighboring gene 60S ribosomal protein L19-like Neighboring gene katanin regulatory subunit B1 like 1 Neighboring gene ER membrane protein complex subunit 4 Neighboring gene small nucleolar RNA SNORA11 Neighboring gene cholinergic receptor, muscarinic 5 Neighboring gene apoptosis and caspase activation inhibitor Neighboring gene proteasome subunit beta type-3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Defining human ERAD networks through an integrative mapping strategy. Christianson JC, et al. Nat Cell Biol, 2011 Nov 27. PMID 22119785, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to membrane insertase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISO
Inferred from Sequence Orthology
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EMC complex ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ER membrane protein complex subunit 7
Names
UPF0480 protein C15orf24 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399270.1 → NP_001386199.1  ER membrane protein complex subunit 7 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HP51, D3ZQL1
    Related
    ENSRNOP00000008364.6, ENSRNOT00000008364.9
    Conserved Domains (1) summary
    pfam09430
    Location:56 → 167
    DUF2012; Protein of unknown function (DUF2012)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    119714617..119728748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591570.3 → XP_017447059.1  ER membrane protein complex subunit 7 isoform X1

    Conserved Domains (1) summary
    pfam09430
    Location:19 → 107
    DUF2012; Protein of unknown function (DUF2012)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106496.1: Suppressed sequence

    Description
    NM_001106496.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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