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Ntrk3 neurotrophic receptor tyrosine kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29613, updated on 27-Nov-2024

Summary

Official Symbol
Ntrk3provided by RGD
Official Full Name
neurotrophic receptor tyrosine kinase 3provided by RGD
Primary source
RGD:3214
See related
EnsemblRapid:ENSRNOG00000018674 AllianceGenome:RGD:3214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
trkC
Summary
Enables GPI-linked ephrin receptor activity. Involved in several processes, including negative regulation of astrocyte differentiation; nervous system development; and response to corticosterone. Is active in glutamatergic synapse and postsynaptic membrane. Biomarker of borna disease. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 154.8), Adrenal (RPKM 34.0) and 6 other tissues See more
Orthologs
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Genomic context

See Ntrk3 in Genome Data Viewer
Location:
1q31
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (141526192..141913575, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (132116472..132503849, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (139890537..140262503, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099860 Neighboring gene uncharacterized LOC102553862 Neighboring gene uncharacterized LOC120099861 Neighboring gene uncharacterized LOC134485141 Neighboring gene uncharacterized LOC103691168 Neighboring gene mitochondrial ribosomal protein L46

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GPI-linked ephrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables boss receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables brain-derived neurotrophic factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables epidermal growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables hepatocyte growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXY142 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3Y41 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables insulin-like growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables macrophage colony-stimulating factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables neurotrophin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neurotrophin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neurotrophin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables neurotrophin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables p53 binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables placental growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables platelet-derived growth factor alpha-receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables platelet-derived growth factor beta-receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase collagen receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables stem cell factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane-ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables vascular endothelial growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Kit signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of axon extension involved in regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nerve growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in cochlea development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in ephrin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hepatocyte growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lens fiber cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage colony-stimulating factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mechanoreceptor differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within myelination in peripheral nervous system ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuronal action potential propagation ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotrophin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of axon extension involved in regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic density assembly EXP
Inferred from Experiment
more info
PubMed 
involved_in postsynaptic density assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of presynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of presynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to axon injury IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NT-3 growth factor receptor
Names
GP145-TrkC
neural receptor protein-tyrosine kinase (trkC)
neurotrophic tyrosine kinase, receptor, type 3
trk-C
trkC tyrosine kinase
NP_001257584.1
NP_001257585.1
NP_062121.1
XP_008757735.1
XP_038965559.1
XP_038965566.1
XP_063143774.1
XP_063143787.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270655.1NP_001257584.1  NT-3 growth factor receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001257584.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    L03813, L14446
    UniProtKB/TrEMBL
    A0A8L2ULV7
    Related
    ENSRNOP00000049463.2, ENSRNOT00000045165.5
    Conserved Domains (7) summary
    cd05094
    Location:532832
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:214299
    ig; Immunoglobulin domain
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:218221
    Ig; Ig strand A' [structural motif]
    cd04971
    Location:304396
    IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
  2. NM_001270656.1NP_001257585.1  NT-3 growth factor receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001257585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcritp and encodes the longest isoform (1).
    Source sequence(s)
    L03813, L14447
    UniProtKB/Swiss-Prot
    Q03351
    UniProtKB/TrEMBL
    A0A8L2ULV7
    Related
    ENSRNOP00000044402.5, ENSRNOT00000046849.7
    Conserved Domains (8) summary
    cd05094
    Location:532857
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:214299
    ig; Immunoglobulin domain
    pfam01462
    Location:3151
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:218221
    Ig; Ig strand A' [structural motif]
    cd04971
    Location:304396
    IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
  3. NM_019248.2NP_062121.1  NT-3 growth factor receptor isoform 3 precursor

    See identical proteins and their annotated locations for NP_062121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    L03813, L14445
    UniProtKB/TrEMBL
    A0A8L2ULV7
    Related
    ENSRNOP00000046059.2, ENSRNOT00000041839.5
    Conserved Domains (7) summary
    cd05094
    Location:532818
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:214299
    ig; Immunoglobulin domain
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:218221
    Ig; Ig strand A' [structural motif]
    cd04971
    Location:304396
    IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    141526192..141913575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287704.1XP_063143774.1  NT-3 growth factor receptor isoform X1

  2. XM_039109638.2XP_038965566.1  NT-3 growth factor receptor isoform X4

    UniProtKB/TrEMBL
    A0A8I6ALQ4
    Conserved Domains (8) summary
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:214299
    ig; Immunoglobulin domain
    pfam01462
    Location:3151
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:218221
    Ig; Ig strand A' [structural motif]
    cd04971
    Location:304396
    IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    cl21453
    Location:532572
    PKc_like; Protein Kinases, catalytic domain
  3. XM_039109631.2XP_038965559.1  NT-3 growth factor receptor isoform X2

    UniProtKB/TrEMBL
    A0A8I6ALQ4
    Conserved Domains (8) summary
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:214299
    ig; Immunoglobulin domain
    pfam01462
    Location:3151
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:218221
    Ig; Ig strand A' [structural motif]
    cd04971
    Location:304396
    IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    cl21453
    Location:532572
    PKc_like; Protein Kinases, catalytic domain
  4. XM_008759513.4XP_008757735.1  NT-3 growth factor receptor isoform X3

    See identical proteins and their annotated locations for XP_008757735.1

    UniProtKB/TrEMBL
    A0A8I6ALQ4, Q68G04
    Related
    ENSRNOP00000094926.2, ENSRNOT00000110436.2
    Conserved Domains (7) summary
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:214299
    ig; Immunoglobulin domain
    pfam01462
    Location:3151
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:218221
    Ig; Ig strand A' [structural motif]
    cd04971
    Location:304396
    IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
  5. XM_063287717.1XP_063143787.1  NT-3 growth factor receptor isoform X3

    UniProtKB/TrEMBL
    Q68G04