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Kif3b kinesin family member 3B [ Rattus norvegicus (Norway rat) ]

Gene ID: 296284, updated on 27-Nov-2024

Summary

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Official Symbol
Kif3bprovided by RGD
Official Full Name
kinesin family member 3Bprovided by RGD
Primary source
RGD:1306815
See related
EnsemblRapid:ENSRNOG00000010361 AllianceGenome:RGD:1306815
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables microtubule binding activity. Involved in positive regulation of cytokinesis. Located in axon and midbody. Human ortholog(s) of this gene implicated in retinitis pigmentosa 89. Orthologous to human KIF3B (kinesin family member 3B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 158.1), Brain (RPKM 105.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kif3b in Genome Data Viewer
Location:
3q41
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (162218621..162258191)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141758466..141798012)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148772937..148813342)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene protein O-fucosyltransferase 1 Neighboring gene ribosomal protein L27A like 6 Neighboring gene uncharacterized LOC134486328 Neighboring gene ASXL transcriptional regulator 1 Neighboring gene nucleolar protein 4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Temporal and spatial expression of KIF3B after acute spinal cord injury in adult rats. Yu X, et al. J Mol Neurosci, 2013 Feb. PMID 23093447
  2. miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target. Aguado-Fraile E, et al. PLoS One, 2012. PMID 22962609, Free PMC Article
  3. A role for the spectrin superfamily member Syne-1 and kinesin II in cytokinesis. Fan J, et al. J Cell Sci, 2004 Feb 1. PMID 14709720
  4. KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles. Muresan V, et al. Mol Biol Cell, 1998 Mar. PMID 9487132, Free PMC Article
  5. Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10. Aoki T, et al. BMC Cell Biol, 2009 Jul 28. PMID 19635168, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIF3B gene expression in neurons and microglia is upregulated after spinal cord injury.
    Title: Temporal and spatial expression of KIF3B after acute spinal cord injury in adult rats.
  2. A novel role for miR-127 has been shown in cell adhesion and its regulation by HIF-1alpha. KIF3B is identified for the first time as a miR-127 target.
    Title: miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intraciliary transport particle B binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anterograde dendritic transport of neurotransmitter receptor complex ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary transport ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in opsin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of kinesin II complex ISO
Inferred from Sequence Orthology
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF3B
NP_001099999.1
XP_006235349.1
XP_006235350.1
XP_006235351.1
XP_038960533.1
XP_063139434.1
XP_063139435.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106529.1 → NP_001099999.1  kinesin-like protein KIF3B

    See identical proteins and their annotated locations for NP_001099999.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474050
    UniProtKB/TrEMBL
    A6KHU9, D3ZI07
    Related
    ENSRNOP00000013804.5, ENSRNOT00000013804.8
    Conserved Domains (2) summary
    COG1196
    Location:352 → 614
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01371
    Location:8 → 340
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    162218621..162258191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283365.1 → XP_063139435.1  kinesin-like protein KIF3B isoform X2

  2. XM_039104605.2 → XP_038960533.1  kinesin-like protein KIF3B isoform X1

    UniProtKB/TrEMBL
    A6KHU9, D3ZI07
    Conserved Domains (2) summary
    COG1196
    Location:352 → 614
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01371
    Location:8 → 340
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

  3. XM_063283364.1 → XP_063139434.1  kinesin-like protein KIF3B isoform X1

    UniProtKB/TrEMBL
    A6KHU9, D3ZI07

  4. XM_006235288.3 → XP_006235350.1  kinesin-like protein KIF3B isoform X1

    See identical proteins and their annotated locations for XP_006235350.1

    UniProtKB/TrEMBL
    A6KHU9, D3ZI07
    Related
    ENSRNOP00000101679.1, ENSRNOT00000152985.1
    Conserved Domains (2) summary
    COG1196
    Location:352 → 614
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01371
    Location:8 → 340
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

  5. XM_006235289.5 → XP_006235351.1  kinesin-like protein KIF3B isoform X1

    See identical proteins and their annotated locations for XP_006235351.1

    UniProtKB/TrEMBL
    A6KHU9, D3ZI07
    Conserved Domains (2) summary
    COG1196
    Location:352 → 614
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01371
    Location:8 → 340
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

  6. XM_006235287.5 → XP_006235349.1  kinesin-like protein KIF3B isoform X1

    See identical proteins and their annotated locations for XP_006235349.1

    UniProtKB/TrEMBL
    A6KHU9, D3ZI07
    Conserved Domains (2) summary
    COG1196
    Location:352 → 614
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01371
    Location:8 → 340
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

RNA

  1. XR_010064591.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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