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Cnbd2 cyclic nucleotide binding domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296311, updated on 4-Jan-2025

Summary

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Official Symbol
Cnbd2provided by RGD
Official Full Name
cyclic nucleotide binding domain containing 2provided by RGD
Primary source
RGD:1311678
See related
EnsemblRapid:ENSRNOG00000019992 AllianceGenome:RGD:1311678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cnmpd1; LRRGT00127
Summary
Predicted to enable cAMP binding activity. Predicted to be involved in spermatogenesis. Predicted to be located in cytosol. Predicted to be part of ribonucleoprotein complex. Orthologous to human CNBD2 (cyclic nucleotide binding domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 185.8), Brain (RPKM 134.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cnbd2 in Genome Data Viewer
Location:
3q42
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (165279157..165357582)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (144819166..144884825)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (152382245..152448105)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene reactive oxygen species modulator 1 Neighboring gene RNA binding motif protein 39 Neighboring gene PHD finger protein 20 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene SCAN domain-containing 1 Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene ferritin light chain 1 pseudogene Neighboring gene erythrocyte membrane protein band 4.1-like 1 Neighboring gene AAR2 splicing factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending. Krähling AM, et al. PLoS Genet, 2013. PMID 24339785, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclic nucleotide-binding domain-containing protein 2
Names
cyclic nucleotide (cNMP) binding domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304368.1 → NP_001291297.1  cyclic nucleotide-binding domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AJL9, A6KIA6
    Related
    ENSRNOP00000093432.2, ENSRNOT00000095390.2
    Conserved Domains (2) summary
    COG0664
    Location:253 → 348
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:250 → 349
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    165279157..165357582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283375.1 → XP_063139445.1  cyclic nucleotide-binding domain-containing protein 2 isoform X4

  2. XM_063283374.1 → XP_063139444.1  cyclic nucleotide-binding domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6KIA6

  3. XM_039104613.2 → XP_038960541.1  cyclic nucleotide-binding domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A6KIA6

  4. XM_039104614.2 → XP_038960542.1  cyclic nucleotide-binding domain-containing protein 2 isoform X5

    Conserved Domains (1) summary
    cd00038
    Location:250 → 349
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  5. XM_008762320.4 → XP_008760542.2  cyclic nucleotide-binding domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A6KIA6
    Related
    ENSRNOP00000112305.1, ENSRNOT00000147018.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177681.1: Suppressed sequence

    Description
    NM_001177681.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript or this protein.
Nucleotide Protein Strain
Heading Accession and Version

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