Mybl2 MYB proto-oncogene like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mybl2provided by RGD
Official Full Name: MYB proto-oncogene like 2provided by RGD
Primary source: RGD:1308474
See related: EnsemblRapid:ENSRNOG00000007805 AllianceGenome:RGD:1308474
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of neuron apoptotic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Myb complex. Predicted to be active in nucleus. Orthologous to human MYBL2 (MYB proto-oncogene like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 58.1), Thymus (RPKM 54.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (172124765..172153221)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (151705254..151733714)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (159421638..159450087)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-423-5p suppression reduced hypoxia/reoxygenation-induced cardiomyocytes injury through activation of the wnt/beta-catenin signaling pathway via targeting MYBL2 in cardiomyocytes
Title: MiR-423-5p inhibition alleviates cardiomyocyte apoptosis and mitochondrial dysfunction caused by hypoxia/reoxygenation through activation of the wnt/β-catenin signaling pathway via targeting MYBL2.
Reduction of B-Myb in cathepsin L-overexpressing cells revealed that regulation of cell cycle-related proteins, including cyclin A and cyclin B1, through cathepsin L was mediated by the transcription factor B-Myb.
Title: Cathepsin L induced PC-12 cell apoptosis via activation of B-Myb and regulation of cell cycle proteins.
Mybl2 upregulation induces fast growth and progression of premalignant and malignant liver, through cell cycle deregulation and activation of genes and pathways related to tumor progression.
Title: Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.
proliferation-inhibiting A(2B)AR is itself an inducible receptor regulated by B-Myb.
Title: B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134987 (e-PCR)
- UniSTS:218264

BI292471 (e-PCR)
- UniSTS:245232

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Myb complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myb-related protein B

Names: myeloblastosis oncogene-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106536.2 → NP_001100006.1 myb-related protein B isoform 1

See identical proteins and their annotated locations for NP_001100006.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JX14, D3ZLC6

Related

ENSRNOP00000106433.1, ENSRNOT00000128666.1

Conserved Domains (4) summary

smart00717
Location:83 → 131

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:83 → 129

Myb_DNA-binding; Myb-like DNA-binding domain

pfam09316
Location:455 → 599

Cmyb_C; C-myb, C-terminal

pfam13921
Location:34 → 94

Myb_DNA-bind_6; Myb-like DNA-binding domain
NM_001430185.1 → NP_001417114.1 myb-related protein B isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

172124765..172153221

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235525.5 → XP_006235587.1 myb-related protein B isoform X1

Related

ENSRNOP00000010343.6, ENSRNOT00000010343.8

Conserved Domains (4) summary

smart00717
Location:83 → 131

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:83 → 129

Myb_DNA-binding; Myb-like DNA-binding domain

pfam09316
Location:455 → 600

Cmyb_C; C-myb, C-terminal

pfam13921
Location:34 → 94

Myb_DNA-bind_6; Myb-like DNA-binding domain