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Ptpn5 protein tyrosine phosphatase, non-receptor type 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29644, updated on 27-Nov-2024

Summary

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Official Symbol
Ptpn5provided by RGD
Official Full Name
protein tyrosine phosphatase, non-receptor type 5provided by RGD
Primary source
RGD:3448
See related
EnsemblRapid:ENSRNOG00000013981 AllianceGenome:RGD:3448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
STEP
Summary
Enables identical protein binding activity and protein tyrosine phosphatase activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of establishment of protein localization; and regulation of protein phosphorylation. Located in several cellular components, including perikaryon; proximal dendrite; and synaptic vesicle. Used to study transient cerebral ischemia. Biomarker of transient cerebral ischemia. Orthologous to human PTPN5 (protein tyrosine phosphatase non-receptor type 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 86.1) See more
Orthologs
human mouse all
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Genomic context

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See Ptpn5 in Genome Data Viewer
Location:
1q22
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (106756896..106817369, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (97620638..97681186, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (103197918..103258309, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 86A Neighboring gene immunoglobulin superfamily member 22 Neighboring gene uncharacterized LOC134483119 Neighboring gene uncharacterized LOC120099813 Neighboring gene MAS related GPR family member X3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Alterations of STEP46 and STEP61 Expression in the Rat Retina with Age and AMD-Like Retinopathy Development. Telegina DV, et al. Int J Mol Sci, 2020 Jul 22. PMID 32707818, Free PMC Article
  2. Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase. Boulanger LM, et al. J Neurosci, 1995 Feb. PMID 7869116, Free PMC Article
  3. A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures. Lombroso PJ, et al. J Neurosci, 1993 Jul. PMID 8331384, Free PMC Article
  4. Overexpression of striatal enriched phosphatase (STEP) promotes the neurite outgrowth induced by a cAMP analogue in PC12 cells. Okamura A, et al. Brain Res Mol Brain Res, 1999 Apr 6. PMID 10101226
  5. Hypoxia-ischemia in perinatal rat brain induces the formation of a low molecular weight isoform of striatal enriched tyrosine phosphatase (STEP). Gurd JW, et al. J Neurochem, 1999 Nov. PMID 10537057

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impairment of neuronal tyrosine phosphatase STEP worsens post-ischemic inflammation and brain injury under hypertensive condition.
    Title: Impairment of neuronal tyrosine phosphatase STEP worsens post-ischemic inflammation and brain injury under hypertensive condition.
  2. Alterations of STEP46 and STEP61 Expression in the Rat Retina with Age and AMD-Like Retinopathy Development.
    Title: Alterations of STEP46 and STEP61 Expression in the Rat Retina with Age and AMD-Like Retinopathy Development.
  3. activation of synaptic NMDAR by bicuculline or D-serine results in the ubiquitination and proteasomal degradation of STEP61, and increased surface localization of GluN1/GluN2B receptors.
    Title: Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP(61).
  4. findings suggest that Src and STEP recruitment is contingent on differing intracellular Ca(2+) dynamics that dictate whether NMDAR function is augmented or depressed following M1R stimulation
    Title: STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit.
  5. It is involved in the etiology of several age-associated neurologic disorders linked to oxidative stress and is also known to play a role in neuroprotection by modulating glutamatergic transmission.
    Title: Aging is associated with dimerization and inactivation of the brain-enriched tyrosine phosphatase STEP.
  6. activity-dependent regulation of STEP61 and its substrates GluN2B and GluA2 may contribute to homeostatic stabilization of excitatory synapses.
    Title: Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity.
  7. The study provides further insight into the mechanisms of regulation of STEP61 and also offers a molecular basis for the Zn(2+)-induced sustained activation of ERK2.
    Title: Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION.
  8. These results indicate that STEP61 is a novel substrate of parkin, although further studies are necessary to determine whether elevated STEP61 levels directly contribute to the pathophysiology of PD.
    Title: STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease.
  9. The findings indicate a neuroprotective role of STEP and suggest a potential role of the STEP-derived peptide in stroke therapy.
    Title: Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia.
  10. Previously characterized pathways of STEP regulation via the NMDA receptor are generally conserved in mechanical injury, correlating the amount of STEP formed and the degree of cell death observed after lethal stretch injury.
    Title: In vitro stretch injury induces time- and severity-dependent alterations of STEP phosphorylation and proteolysis in neurons.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in exploration behavior IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of response to drug IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to amphetamine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to immobilization stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in proximal dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 5
Names
neural-specific protein-tyrosine phosphatase
protein-tyrosine phosphatase striatum-enriched
protein-tyrosine-phosphatase non-receptor 5
striatum-enriched protein-tyrosine phosphatase
NP_001385534.1
XP_006229316.1
XP_006229319.1
XP_038965611.1
XP_038965615.1
XP_038965619.1
XP_038965622.1
XP_038965626.1
XP_038965627.1
XP_038965631.1
XP_063143815.1
XP_063143827.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398605.1 → NP_001385534.1  tyrosine-protein phosphatase non-receptor type 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2QC31
    Related
    ENSRNOP00000018860.6, ENSRNOT00000018860.8
    Conserved Domains (1) summary
    cd14613
    Location:317 → 574
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    106756896..106817369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109694.2 → XP_038965622.1  tyrosine-protein phosphatase non-receptor type 5 isoform X2

    Conserved Domains (1) summary
    cd14613
    Location:326 → 583
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

  2. XM_039109687.2 → XP_038965615.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    Conserved Domains (1) summary
    cd14613
    Location:346 → 603
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

  3. XM_063287757.1 → XP_063143827.1  tyrosine-protein phosphatase non-receptor type 5 isoform X5

    Related
    ENSRNOP00000111270.1, ENSRNOT00000134129.1

  4. XM_039109699.2 → XP_038965627.1  tyrosine-protein phosphatase non-receptor type 5 isoform X3

    Conserved Domains (1) summary
    cd14613
    Location:318 → 575
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

  5. XM_039109691.2 → XP_038965619.1  tyrosine-protein phosphatase non-receptor type 5 isoform X2

    Conserved Domains (1) summary
    cd14613
    Location:326 → 583
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

  6. XM_039109683.2 → XP_038965611.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    Conserved Domains (1) summary
    cd14613
    Location:346 → 603
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

  7. XM_039109703.2 → XP_038965631.1  tyrosine-protein phosphatase non-receptor type 5 isoform X4

    Conserved Domains (1) summary
    cd14613
    Location:302 → 559
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

  8. XM_006229254.5 → XP_006229316.1  tyrosine-protein phosphatase non-receptor type 5 isoform X5

    Related
    ENSRNOP00000107278.1, ENSRNOT00000165423.1
    Conserved Domains (2) summary
    smart00194
    Location:298 → 551
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:324 → 551
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  9. XM_006229257.5 → XP_006229319.1  tyrosine-protein phosphatase non-receptor type 5 isoform X6

    Related
    ENSRNOP00000099754.1, ENSRNOT00000145318.1
    Conserved Domains (2) summary
    smart00194
    Location:274 → 527
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:300 → 527
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  10. XM_039109698.1 → XP_038965626.1  tyrosine-protein phosphatase non-receptor type 5 isoform X2

    Conserved Domains (1) summary
    cd14613
    Location:326 → 583
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

  11. XM_063287745.1 → XP_063143815.1  tyrosine-protein phosphatase non-receptor type 5 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019253.4: Suppressed sequence

    Description
    NM_019253.4: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35234.2 GenPept UniProtKB/Swiss-Prot:P35234

Gene LinkOut

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