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Fmn1 formin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296512, updated on 4-Jan-2025

Summary

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Symbol
Fmn1provided by RGD
Full Name
formin 1provided by RGD
Primary source
RGD:1306349
See related
EnsemblRapid:ENSRNOG00000031760 AllianceGenome:RGD:1306349
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306349; RGD1310100
Summary
Predicted to enable SH3 domain binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within several processes, including limb morphogenesis; positive regulation of cellular component organization; and ureteric bud invasion. Predicted to be located in cytoplasm. Predicted to be active in endoplasmic reticulum membrane and nucleus. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human FMN1 (formin 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 68.4), Brain (RPKM 49.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fmn1 in Genome Data Viewer
Location:
3q35
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (120555445..120939978)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (100101103..100485652)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (104783093..105170761)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101626 Neighboring gene WD repeat domain 12, pseudogene 1 Neighboring gene transmembrane and coiled-coil domains 5B Neighboring gene large ribosomal subunit protein eL33-like Neighboring gene twinfilin-2-like Neighboring gene mRNA turnover 4, ribosome maturation factor, pseudogene 4 Neighboring gene sorbitol dehydrogenase, pseudogene 5 Neighboring gene gremlin 1, DAN family BMP antagonist

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Formin 1 Regulates Microtubule and F-Actin Organization to Support Spermatid Transport During Spermatogenesis in the Rat Testis. Li N, et al. Endocrinology, 2016 Jul. PMID 27145014, Free PMC Article
  2. Formin 1 Regulates Ectoplasmic Specialization in the Rat Testis Through Its Actin Nucleation and Bundling Activity. Li N, et al. Endocrinology, 2015 Aug. PMID 25901598, Free PMC Article
  3. Formin 1-isoform IV deficient cells exhibit defects in cell spreading and focal adhesion formation. Dettenhofer M, et al. PLoS One, 2008 Jun 18. PMID 18560567, Free PMC Article
  4. Actin coating and compression of fused secretory vesicles are essential for surfactant secretion--a role for Rho, formins and myosin II. Miklavc P, et al. J Cell Sci, 2012 Jun 1. PMID 22427691
  5. Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2. Zhou F, et al. Exp Cell Res, 2006 Apr 15. PMID 16480715

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In summary, formin1 maintains MT and F-actin track-like structures to support spermatid and phagosome transport across the seminiferous epithelium during spermatogenesis.
    Title: Formin 1 Regulates Microtubule and F-Actin Organization to Support Spermatid Transport During Spermatogenesis in the Rat Testis.
  2. Formin 1 is a regulator of ectoplasmic specialization dynamics in the testis.
    Title: Formin 1 Regulates Ectoplasmic Specialization in the Rat Testis Through Its Actin Nucleation and Bundling Activity.
  3. Initial actin coating of fused vesicles is dependent on activation of Rho and formin-dependent actin nucleation. Actin coat contraction is facilitated by myosin II.
    Title: Actin coating and compression of fused secretory vesicles are essential for surfactant secretion--a role for Rho, formins and myosin II.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin nucleation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within limb development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of actin nucleation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ureteric bud invasion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin filament IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
formin 1; formin-1
Names
mRNA turnover protein 4 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    120555445..120939978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285290.1 → XP_063141360.1  formin-1 isoform X4

  2. XM_039106467.2 → XP_038962395.1  formin-1 isoform X1

    UniProtKB/TrEMBL
    D4A4Y9
    Related
    ENSRNOP00000042712.6, ENSRNOT00000042103.6
    Conserved Domains (1) summary
    smart00498
    Location:983 → 1380
    FH2; Formin Homology 2 Domain

  3. XM_063285289.1 → XP_063141359.1  formin-1 isoform X2

    UniProtKB/TrEMBL
    D4A4Y9, D4A7C2
    Related
    ENSRNOP00000047506.6, ENSRNOT00000044625.7

  4. XM_063285292.1 → XP_063141362.1  formin-1 isoform X6

    UniProtKB/TrEMBL
    A6HP62

  5. XM_063285293.1 → XP_063141363.1  formin-1 isoform X7

    UniProtKB/TrEMBL
    A6HP62

  6. XM_039106466.2 → XP_038962394.1  formin-1 isoform X1

    UniProtKB/TrEMBL
    D4A4Y9
    Conserved Domains (1) summary
    smart00498
    Location:983 → 1380
    FH2; Formin Homology 2 Domain

  7. XM_063285291.1 → XP_063141361.1  formin-1 isoform X4

  8. XM_039106468.2 → XP_038962396.1  formin-1 isoform X1

    UniProtKB/TrEMBL
    D4A4Y9
    Conserved Domains (1) summary
    smart00498
    Location:983 → 1380
    FH2; Formin Homology 2 Domain

  9. XM_039106472.2 → XP_038962400.1  formin-1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GJL6
    Related
    ENSRNOP00000091414.1, ENSRNOT00000114830.2
    Conserved Domains (1) summary
    smart00498
    Location:371 → 768
    FH2; Formin Homology 2 Domain

  10. XM_039106470.2 → XP_038962398.1  formin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AHH7, D3ZBI5
    Related
    ENSRNOP00000094328.1, ENSRNOT00000098989.2
    Conserved Domains (2) summary
    smart00498
    Location:759 → 1156
    FH2; Formin Homology 2 Domain
    PHA03169
    Location:61 → 240
    PHA03169; hypothetical protein; Provisional

  11. XM_039106474.2 → XP_038962402.1  formin-1 isoform X8

    Conserved Domains (1) summary
    smart00498
    Location:198 → 595
    FH2; Formin Homology 2 Domain
Nucleotide Protein Strain
Heading Accession and Version

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