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Bmal1 basic helix-loop-helix ARNT like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29657, updated on 4-Jan-2025

Summary

Official Symbol
Bmal1provided by RGD
Official Full Name
basic helix-loop-helix ARNT like 1provided by RGD
Primary source
RGD:62003
See related
EnsemblRapid:ENSRNOG00000014448 AllianceGenome:RGD:62003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Arntl
Summary
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. [provided by RefSeq, Jan 2014]
Expression
Biased expression in Thymus (RPKM 162.2), Liver (RPKM 123.4) and 9 other tissues See more
Orthologs
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Genomic context

See Bmal1 in Genome Data Viewer
Location:
1q33
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (176766222..176864741)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (167331756..167430235)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (178039002..178137469)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cytoskeleton-associated protein 2, pseudogene 3 Neighboring gene uncharacterized LOC120099909 Neighboring gene BTB domain containing 10 Neighboring gene uncharacterized LOC134484822 Neighboring gene RNA, U6 small nuclear 26

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables E-box binding IEA
Inferred from Electronic Annotation
more info
 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables aryl hydrocarbon receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables aryl hydrocarbon receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in maternal process involved in parturition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of glucocorticoid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glucocorticoid receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oxidative stress-induced premature senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in oxidative stress-induced premature senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein acetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein acetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of skeletal muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of hair cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of hair cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of hair cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of type B pancreatic cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of type B pancreatic cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to redox state IEA
Inferred from Electronic Annotation
more info
 
involved_in response to redox state ISO
Inferred from Sequence Orthology
more info
 
involved_in response to redox state ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of CLOCK-BMAL transcription complex IEA
Inferred from Electronic Annotation
more info
 
part_of CLOCK-BMAL transcription complex ISO
Inferred from Sequence Orthology
more info
 
located_in PML body IEA
Inferred from Electronic Annotation
more info
 
part_of aryl hydrocarbon receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromatoid body ISO
Inferred from Sequence Orthology
more info
 
located_in chromatoid body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
basic helix-loop-helix ARNT-like protein 1
Names
aryl hydrocarbon receptor nuclear translocator-like protein 1
brain and muscle ARNT-like 1
tic

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024362.2NP_077338.2  basic helix-loop-helix ARNT-like protein 1

    See identical proteins and their annotated locations for NP_077338.2

    Status: VALIDATED

    Source sequence(s)
    BC099833
    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    UniProtKB/TrEMBL
    A6I877, D3ZT62
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:339441
    PAS_11; PAS domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    176766222..176864741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230029.5XP_006230091.1  basic helix-loop-helix ARNT-like protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006230091.1

    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    UniProtKB/TrEMBL
    A6I877, D3ZT62
    Related
    ENSRNOP00000042830.3, ENSRNOT00000046313.6
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:339441
    PAS_11; PAS domain
  2. XM_017589065.3XP_017444554.1  basic helix-loop-helix ARNT-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    UniProtKB/TrEMBL
    A0A8I5ZXD2, A6I875
    Conserved Domains (3) summary
    smart00091
    Location:156215
    PAS; PAS domain
    cd11438
    Location:74137
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:346448
    PAS_11; PAS domain
  3. XM_017589068.3XP_017444557.1  basic helix-loop-helix ARNT-like protein 1 isoform X2

    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    Conserved Domains (3) summary
    smart00091
    Location:156215
    PAS; PAS domain
    cd11438
    Location:74137
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:345447
    PAS_11; PAS domain
  4. XM_006230030.5XP_006230092.1  basic helix-loop-helix ARNT-like protein 1 isoform X4

    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:338440
    PAS_11; PAS domain
  5. XM_039109748.2XP_038965676.1  basic helix-loop-helix ARNT-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    UniProtKB/TrEMBL
    A0A8I5ZXD2, A6I875
    Conserved Domains (3) summary
    smart00091
    Location:156215
    PAS; PAS domain
    cd11438
    Location:74137
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:346448
    PAS_11; PAS domain
  6. XM_063287814.1XP_063143884.1  basic helix-loop-helix ARNT-like protein 1 isoform X3

    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    UniProtKB/TrEMBL
    A6I877, D3ZT62
  7. XM_017589067.3XP_017444556.1  basic helix-loop-helix ARNT-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    UniProtKB/TrEMBL
    A0A8I5ZXD2, A6I875
    Conserved Domains (3) summary
    smart00091
    Location:156215
    PAS; PAS domain
    cd11438
    Location:74137
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:346448
    PAS_11; PAS domain
  8. XM_039109755.2XP_038965683.1  basic helix-loop-helix ARNT-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    UniProtKB/TrEMBL
    A0A8I5ZXD2, A6I875
    Conserved Domains (3) summary
    smart00091
    Location:156215
    PAS; PAS domain
    cd11438
    Location:74137
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:346448
    PAS_11; PAS domain
  9. XM_063287804.1XP_063143874.1  basic helix-loop-helix ARNT-like protein 1 isoform X3

    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    UniProtKB/TrEMBL
    A6I877, D3ZT62
  10. XM_063287791.1XP_063143861.1  basic helix-loop-helix ARNT-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    UniProtKB/TrEMBL
    A0A8I5ZXD2, A6I875
    Related
    ENSRNOP00000082167.1, ENSRNOT00000095012.2
  11. XM_017589070.3XP_017444559.1  basic helix-loop-helix ARNT-like protein 1 isoform X6

    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    UniProtKB/TrEMBL
    A0A8I6A2N7
    Related
    ENSRNOP00000087129.1, ENSRNOT00000097013.2
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:296398
    PAS_11; PAS domain
  12. XM_039109788.2XP_038965716.1  basic helix-loop-helix ARNT-like protein 1 isoform X7

    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:295397
    PAS_11; PAS domain
  13. XM_039109778.1XP_038965706.1  basic helix-loop-helix ARNT-like protein 1 isoform X5

    UniProtKB/Swiss-Prot
    O88337, O88810, Q499M8, Q9EPW1
    Conserved Domains (3) summary
    smart00091
    Location:132191
    PAS; PAS domain
    cd11438
    Location:50113
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:322424
    PAS_11; PAS domain