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Asb6 ankyrin repeat and SOCS box-containing 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296627, updated on 4-Jan-2025

Summary

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Official Symbol
Asb6provided by RGD
Official Full Name
ankyrin repeat and SOCS box-containing 6provided by RGD
Primary source
RGD:1308445
See related
EnsemblRapid:ENSRNOG00000024786 AllianceGenome:RGD:1308445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB6 (ankyrin repeat and SOCS box containing 6). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 52.1), Thymus (RPKM 51.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Asb6 in Genome Data Viewer
Location:
3p12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (34508390..34513033, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (14110628..14115274, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (9659707..9664445, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 9 open reading frame 50 Neighboring gene N-terminal Xaa-Pro-Lys N-methyltransferase 1 Neighboring gene paired related homeobox 2 Neighboring gene prostaglandin E synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 6
Names
ankyrin repeat and SOCS box-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011963.3 → NP_001011963.1  ankyrin repeat and SOCS box protein 6 isoform 2

    See identical proteins and their annotated locations for NP_001011963.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6ANG1, Q6AYC9
    Related
    ENSRNOP00000031019.3, ENSRNOT00000034927.5
    Conserved Domains (4) summary
    cd00204
    Location:29 → 139
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03725
    Location:295 → 338
    SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
    pfam12796
    Location:32 → 131
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:30 → 58
    ANK; ANK repeat [structural motif]

  2. NM_001399347.1 → NP_001386276.1  ankyrin repeat and SOCS box protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JU05, A6JU06
    Related
    ENSRNOP00000097464.2, ENSRNOT00000105180.2
    Conserved Domains (3) summary
    PHA03095
    Location:86 → 282
    PHA03095; ankyrin-like protein; Provisional
    cd03725
    Location:368 → 411
    SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
    sd00045
    Location:103 → 131
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    34508390..34513033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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