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Ap1b1 adaptor related protein complex 1 subunit beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29663, updated on 27-Nov-2024

Summary

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Official Symbol
Ap1b1provided by RGD
Official Full Name
adaptor related protein complex 1 subunit beta 1provided by RGD
Primary source
RGD:2064
See related
EnsemblRapid:ENSRNOG00000008786 AllianceGenome:RGD:2064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Adtb1
Summary
Enables protein serine/threonine kinase binding activity. Involved in clathrin coat assembly. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of clathrin coat. Predicted to be active in synaptic vesicle. Orthologous to human AP1B1 (adaptor related protein complex 1 subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 235.1), Brain (RPKM 218.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ap1b1 in Genome Data Viewer
Location:
14q21
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84093529..84144835)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (79879482..79930778)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85230652..85281806)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene neurofilament heavy chain Neighboring gene uncharacterized LOC134481867 Neighboring gene small nucleolar RNA, C/D box 125 Neighboring gene uncharacterized LOC120096647 Neighboring gene RAS-like, family 10, member A Neighboring gene growth arrest-specific 2 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Direct effects of the angiotensin-converting enzyme inhibitor ramiprilat on adult rat ventricular cardiomyocytes. Helmig S, et al. Acta Physiol (Oxf), 2007 Dec. PMID 17825088
  2. Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia. Nijboer CH, et al. Stroke, 2009 Oct. PMID 19628795
  3. Matrix metalloproteinase-3 induction in rat brain astrocytes: focus on the role of two AP-1 elements. Kim KS, et al. Biochem J, 2008 Mar 15. PMID 18072934
  4. Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene. Peyrard M, et al. Hum Mol Genet, 1994 Aug. PMID 7987321
  5. Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney. Jung KJ, et al. Inflamm Res, 2009 Mar. PMID 19199090

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our data indicate that the switch to JNK/AP-1 activation preserves HI-induced TNF-alpha expression and thereby might contribute to the neuroprotective effect of TAT-NBD possibly through a TNF-R2 dependent mechanism.
    Title: Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia.
  2. Results suggest that 10-day calorie restriction can attenuate the altered signal transduction for inflammatory processes which is mediated through reactive species-induced NF-kB and AP-1 in aged kidney.
    Title: Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney.
  3. results indicate that AP-1 could control MMP-3 induction in brain astrocytes and that its regulation through specific AP-1 elements could be exploited in the treatment of brain pathologies in which increased expression of MMP-3 plays crucial roles
    Title: Matrix metalloproteinase-3 induction in rat brain astrocytes: focus on the role of two AP-1 elements.
  4. Ramiprilat exerts direct, bradykinin-receptor independent effects on cardiomyocytes that improve cellular function without a corresponding effect on AP-1 activation or induction of AP-1 dependent effects.
    Title: Direct effects of the angiotensin-converting enzyme inhibitor ramiprilat on adult rat ventricular cardiomyocytes.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables clathrin binding IC
Inferred by Curator
more info
 PubMed 
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin coat assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin coat IC
Inferred by Curator
more info
 PubMed 
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AP-1 complex subunit beta-1
Names
adaptor-related protein complex 1, beta 1 subunit
adaptor-related protein complex AP-1 beta 1 subunit
beta-adaptin 1
clathrin assembly protein complex 1 beta large chain
golgi adaptor HA1/AP1 adaptin beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308298.1 → NP_001295227.1  AP-1 complex subunit beta-1

    See identical proteins and their annotated locations for NP_001295227.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    P52303
    UniProtKB/TrEMBL
    A0A0G2K2V2, A6IKJ5
    Related
    ENSRNOP00000072388.3, ENSRNOT00000089866.3
    Conserved Domains (5) summary
    smart00809
    Location:729 → 829
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:838 → 948
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region
    pfam12717
    Location:99 → 268
    Cnd1; non-SMC mitotic condensation complex subunit 1
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    84093529..84144835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273010.1 → XP_063129080.1  AP-1 complex subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    A6IKJ6, G3V9N8

  2. XM_063273009.1 → XP_063129079.1  AP-1 complex subunit beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2V2, A6IKJ5

  3. XM_063273008.1 → XP_063129078.1  AP-1 complex subunit beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2V2, A6IKJ5
    Related
    ENSRNOP00000054218.6, ENSRNOT00000057407.6

  4. XM_039091797.2 → XP_038947725.1  AP-1 complex subunit beta-1 isoform X2

    UniProtKB/Swiss-Prot
    P52303
    UniProtKB/TrEMBL
    A6IKJ6, G3V9N8
    Related
    ENSRNOP00000096766.1, ENSRNOT00000115824.2
    Conserved Domains (4) summary
    smart00809
    Location:722 → 822
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:831 → 941
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  5. XM_063273011.1 → XP_063129081.1  AP-1 complex subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    A6IKJ6, G3V9N8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52303.1 GenPept UniProtKB/Swiss-Prot:P52303

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