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Plpp7 phospholipid phosphatase 7 (inactive) [ Rattus norvegicus (Norway rat) ]

Gene ID: 296635, updated on 27-Nov-2024

Summary

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Official Symbol
Plpp7provided by RGD
Official Full Name
phospholipid phosphatase 7 (inactive)provided by RGD
Primary source
RGD:1305821
See related
EnsemblRapid:ENSRNOG00000010068 AllianceGenome:RGD:1305821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ppapdc3; RGD1305821
Summary
Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to act upstream of or within negative regulation of myotube differentiation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane and nuclear envelope. Orthologous to human PLPP7 (phospholipid phosphatase 7 (inactive)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 556.9), Heart (RPKM 157.4) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Plpp7 in Genome Data Viewer
Location:
3p12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (35782215..35796577)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15384461..15398820)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11114551..11130427)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 78, member A Neighboring gene uncharacterized LOC134486353 Neighboring gene uncharacterized LOC120101521 Neighboring gene proline-rich coiled-coil 2B Neighboring gene small nucleolar RNA, C/D box 62A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of myoblast differentiation by the nuclear envelope protein NET39. Liu GH, et al. Mol Cell Biol, 2009 Nov. PMID 19704009, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109271

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables lipid phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables sphingosine-1-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inactive phospholipid phosphatase 7
Names
phosphatidic acid phosphatase type 2 domain containing 3
phosphatidic acid phosphatase type 2 domain-containing protein 3
probable lipid phosphate phosphatase PPAPDC3
NP_001012349.1
XP_038960681.1
XP_063139561.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012349.2 → NP_001012349.1  inactive phospholipid phosphatase 7

    See identical proteins and their annotated locations for NP_001012349.1

    Status: VALIDATED

    Source sequence(s)
    AA900756, BC089948, CB771354
    UniProtKB/Swiss-Prot
    Q5FVJ3
    UniProtKB/TrEMBL
    A6JU41
    Related
    ENSRNOP00000013507.4, ENSRNOT00000013507.6
    Conserved Domains (2) summary
    COG0671
    Location:123 → 249
    PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
    cd03391
    Location:97 → 255
    PAP2_containing_2_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    35782215..35796577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104753.2 → XP_038960681.1  inactive phospholipid phosphatase 7 isoform X1

    Conserved Domains (1) summary
    cd03391
    Location:39 → 143
    PAP2_containing_2_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a ...

  2. XM_063283491.1 → XP_063139561.1  inactive phospholipid phosphatase 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AEA9
    Related
    ENSRNOP00000090722.1, ENSRNOT00000099438.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVJ3.1 GenPept UniProtKB/Swiss-Prot:Q5FVJ3

Gene LinkOut

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