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Arpc5l actin related protein 2/3 complex, subunit 5-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 296710, updated on 4-Jan-2025

Summary

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Official Symbol
Arpc5lprovided by RGD
Official Full Name
actin related protein 2/3 complex, subunit 5-likeprovided by RGD
Primary source
RGD:1308867
See related
EnsemblRapid:ENSRNOG00000014317 AllianceGenome:RGD:1308867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Arpc5l1
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Predicted to be part of Arp2/3 protein complex. Predicted to be active in cytoplasm and glutamatergic synapse. Orthologous to human ARPC5L (actin related protein 2/3 complex subunit 5 like). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 362.8), Muscle (RPKM 332.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arpc5l in Genome Data Viewer
Location:
3q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (43169518..43177224)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (22758710..22767520)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (23301455..23309077)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA79 Neighboring gene WD repeat domain 38 Neighboring gene ribosomal protein L35 Neighboring gene golgin A1 Neighboring gene uncharacterized LOC134486089 Neighboring gene suppressor of cancer cell invasion like 1 Neighboring gene suppressor of cancer cell invasion

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. Biesemann C, et al. EMBO J, 2014 Jan 13. PMID 24413018, Free PMC Article
  2. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
  3. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112865

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Arp2/3 protein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
actin-related protein 2/3 complex subunit 5-like protein
Names
ARC16-2
actin related protein 2/3 complex, subunit 5-like 1
arp2/3 complex 16 kDa subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037767.2 → NP_001032856.2  actin-related protein 2/3 complex subunit 5-like protein

    See identical proteins and their annotated locations for NP_001032856.2

    Status: VALIDATED

    Source sequence(s)
    BC127445, FM029541
    UniProtKB/Swiss-Prot
    A1L108, Q4KM42
    UniProtKB/TrEMBL
    A0A8L2QA00, A6JEW0
    Related
    ENSRNOP00000019405.8, ENSRNOT00000019405.9
    Conserved Domains (1) summary
    pfam04699
    Location:9 → 151
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    43169518..43177224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104789.2 → XP_038960717.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

    Conserved Domains (1) summary
    pfam04699
    Location:1 → 99
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

  2. XM_063283529.1 → XP_063139599.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

  3. XM_039104791.2 → XP_038960719.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

    Conserved Domains (1) summary
    pfam04699
    Location:1 → 99
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

  4. XM_063283530.1 → XP_063139600.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

  5. XM_063283531.1 → XP_063139601.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

  6. XM_039104793.2 → XP_038960721.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

    Conserved Domains (1) summary
    pfam04699
    Location:1 → 99
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

  7. XM_039104794.2 → XP_038960722.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

    Conserved Domains (1) summary
    pfam04699
    Location:1 → 99
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1L108.2 GenPept UniProtKB/Swiss-Prot:A1L108

Gene LinkOut

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