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Las1l LAS1-like, ribosome biogenesis factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 296865, updated on 9-Dec-2024

Summary

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Official Symbol
Las1lprovided by RGD
Official Full Name
LAS1-like, ribosome biogenesis factorprovided by RGD
Primary source
RGD:1565755
See related
EnsemblRapid:ENSRNOG00000021748 AllianceGenome:RGD:1565755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565755
Summary
Predicted to enable endonuclease activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be located in nucleolus. Predicted to be part of MLL1 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Wilson-Turner syndrome. Orthologous to human LAS1L (LAS1 like ribosome biogenesis factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 103.2), Spleen (RPKM 100.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Las1l in Genome Data Viewer
Location:
Xq22
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (64861472..64883221, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (60851969..60873717, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (65081591..65102344, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X Unlocalized Scaffold NW_007906386.1 (10516..11640, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 12B Neighboring gene alpha- and gamma-adaptin binding protein, pseudogene 1 Neighboring gene DLG associated protein 4, pseudogene 1 Neighboring gene uncharacterized LOC102550969 Neighboring gene small Cajal body-specific RNA 3 Neighboring gene moesin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Dou Y, et al. Cell, 2005 Jun 17. PMID 15960975
  2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC189399

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Las1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribosomal biogenesis protein LAS1L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170590.1 → NP_001164061.1  ribosomal biogenesis protein LAS1L

    Status: VALIDATED

    Source sequence(s)
    BF554409, CB322360, CB751131, CB811034, FM042988, JAXUCZ010000021
    UniProtKB/TrEMBL
    F7FJR8
    Conserved Domains (1) summary
    pfam04031
    Location:28 → 172
    Las1; Las1-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    64861472..64883221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099569.2 → XP_038955497.1  ribosomal biogenesis protein LAS1L isoform X1

    UniProtKB/TrEMBL
    F7FJR8
    Conserved Domains (1) summary
    pfam04031
    Location:28 → 171
    Las1; Las1-like

  2. XM_039099571.2 → XP_038955499.1  ribosomal biogenesis protein LAS1L isoform X3

    UniProtKB/TrEMBL
    F7FJR8
    Related
    ENSRNOP00000016042.7, ENSRNOT00000016042.10
    Conserved Domains (1) summary
    pfam04031
    Location:28 → 171
    Las1; Las1-like

  3. XM_063279874.1 → XP_063135944.1  ribosomal biogenesis protein LAS1L isoform X5

    UniProtKB/TrEMBL
    A0A8I6A8V8, F7FJR8
    Related
    ENSRNOP00000090181.1, ENSRNOT00000076543.3

  4. XM_039099570.2 → XP_038955498.1  ribosomal biogenesis protein LAS1L isoform X2

    UniProtKB/TrEMBL
    A0A096MJM8, F7FJR8
    Related
    ENSRNOP00000068191.2, ENSRNOT00000076732.4
    Conserved Domains (1) summary
    pfam04031
    Location:28 → 171
    Las1; Las1-like

  5. XM_039099572.2 → XP_038955500.1  ribosomal biogenesis protein LAS1L isoform X4

    UniProtKB/TrEMBL
    F7FJR8
    Conserved Domains (1) summary
    pfam04031
    Location:28 → 171
    Las1; Las1-like
Nucleotide Protein Strain
Heading Accession and Version

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