Gabrr2 gamma-aminobutyric acid type A receptor subunit rho 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabrr2provided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit rho 2provided by RGD
Primary source: RGD:61902
See related: EnsemblRapid:ENSRNOG00000007490 AllianceGenome:RGD:61902
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GABA-A receptor activity; protein domain specific binding activity; and transmitter-gated monoatomic ion channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within gamma-aminobutyric acid signaling pathway and visual perception. Is active in GABA-ergic synapse. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human GABRR2 (gamma-aminobutyric acid type A receptor subunit rho2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 17.2), Muscle (RPKM 15.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q21

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (52242564..52286255)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (47445280..47489929)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (48303366..48341571)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of GABA(C) receptors in the cerebellum adds a new dimension to the regulation of GABAergic neurotransmission
Title: Expression of GABArho subunits during rat cerebellum development.
The rho1 and rho2 products appeared to be developmentally regulated; they were found to be more pronounced in adulthood.
Title: gamma-Aminobutyric acidA rho receptor subunits in the developing rat hippocampus.
GABA(C) receptors are specifically involved in aspects of visual image motion processing in the rat brain.
Title: GABA receptor rho subunit expression in the developing rat brain.
The proportion of neurons in the brainstem with immunoreactivity for the GABA(B)R2 subunit included catecholamine and serotonin neurons.
Title: GABAB receptor subunits, R1 and R2, in brainstem catecholamine and serotonin neurons.

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General gene information

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Markers

Gabrr2 (e-PCR), detects polymorphism
- UniSTS:234041

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA-A receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-A receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-A receptor activity	ISO Inferred from Sequence Orthology more info
enables GABA-gated chloride ion channel activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	TAS Traceable Author Statement more info	PubMed
enables inhibitory extracellular ligand-gated monoatomic ion channel activity	TAS Traceable Author Statement more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
NOT acts_upstream_of_or_within eye photoreceptor cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in intracellular vesicle	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit rho-2

Names: GABA(A) receptor subunit rho-2; GABA(C) receptor; GABAAR subunit rho-2; gamma-aminobutyric acid (GABA) A receptor, rho 2; gamma-aminobutyric acid (GABA) receptor, rho 2; gamma-aminobutyric acid (GABA-A) receptor, subunit rho 2; gamma-aminobutyric acid (GABA-C) receptor, subunit rho 2; gamma-aminobutyric acid A receptor, rho 2; gamma-aminobutyric acid type A receptor rho 2 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017292.2 → NP_058988.1 gamma-aminobutyric acid receptor subunit rho-2 precursor

See identical proteins and their annotated locations for NP_058988.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P47742

UniProtKB/TrEMBL

A6IIK8

Related

ENSRNOP00000110953.1, ENSRNOT00000130265.1

Conserved Domains (3) summary

TIGR00860
Location:61 → 464

LIC; Cation transporter family protein

cd03558
Location:178 → 192

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:76 → 261

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

52242564..52286255

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109380.2 → XP_038965308.1 gamma-aminobutyric acid receptor subunit rho-2 isoform X1

UniProtKB/TrEMBL

A6IIK8

Related

ENSRNOP00000100074.1, ENSRNOT00000155034.1

Conserved Domains (2) summary

TIGR00860
Location:87 → 490

LIC; Cation transporter family protein

cd19005
Location:102 → 287

LGIC_ECD_GABAAR_rho; extracellular domain of gamma-aminobutyric acid receptor subunit rho
XM_039109382.2 → XP_038965310.1 gamma-aminobutyric acid receptor subunit rho-2 isoform X3

UniProtKB/TrEMBL

A6IIK8

Conserved Domains (3) summary

TIGR00860
Location:39 → 442

LIC; Cation transporter family protein

cd03558
Location:156 → 170

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:54 → 239

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
XM_039109385.2 → XP_038965313.1 gamma-aminobutyric acid receptor subunit rho-2 isoform X7

Conserved Domains (1) summary

TIGR00860
Location:1 → 308

LIC; Cation transporter family protein
XM_039109381.2 → XP_038965309.1 gamma-aminobutyric acid receptor subunit rho-2 isoform X2

Conserved Domains (2) summary

cd19005
Location:102 → 287

LGIC_ECD_GABAAR_rho; extracellular domain of gamma-aminobutyric acid receptor subunit rho

cd19059
Location:288 → 376

LGIC_TM_GABAAR_rho; transmembrane domain of rho subunits of type-A gamma-aminobutyric acid receptor (GABAAR)
XM_039109384.2 → XP_038965312.1 gamma-aminobutyric acid receptor subunit rho-2 isoform X6

Conserved Domains (3) summary

cd19005
Location:102 → 287

LGIC_ECD_GABAAR_rho; extracellular domain of gamma-aminobutyric acid receptor subunit rho

cd03559
Location:289 → 312

LGIC_TM; TM1 helix [structural motif]

cl38911
Location:288 → 323

LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels
XM_008763611.4 → XP_008761833.1 gamma-aminobutyric acid receptor subunit rho-2 isoform X4

UniProtKB/TrEMBL

A6IIK8

Conserved Domains (2) summary

pfam02931
Location:24 → 214

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:221 → 414

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
XM_063287266.1 → XP_063143336.1 gamma-aminobutyric acid receptor subunit rho-2 isoform X7
XM_039109383.1 → XP_038965311.1 gamma-aminobutyric acid receptor subunit rho-2 isoform X5

Conserved Domains (3) summary

TIGR00860
Location:2 → 365

LIC; Cation transporter family protein

cd03558
Location:79 → 93

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:1 → 162

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))