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Rtkn rhotekin [ Rattus norvegicus (Norway rat) ]

Gene ID: 297383, updated on 9-Dec-2024

Summary

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Symbol
Rtknprovided by RGD
Full Name
rhotekinprovided by RGD
Primary source
RGD:727874
See related
EnsemblRapid:ENSRNOG00000009022 AllianceGenome:RGD:727874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; cytoskeleton-dependent cytokinesis; and septin ring organization. Predicted to be active in actomyosin contractile ring. Orthologous to human RTKN (rhotekin). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 67.7), Kidney (RPKM 44.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rtkn in Genome Data Viewer
Location:
4q34
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117198496..117215660)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115640813..115657952)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (114833453..114850705)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene WW domain binding protein 1 Neighboring gene INO80 complex subunit B Neighboring gene uncharacterized LOC108350719 Neighboring gene WD repeat domain 54 Neighboring gene similar to human chromosome 2 open reading frame 81 Neighboring gene dynactin subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rhotekin modulates differentiation of cultured neural stem cells to neurons. Iwai T, et al. J Neurosci Res, 2012 Jul. PMID 22411704
  2. The indolinone MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells without the inhibition of VEGFR-3 phosphorylation: involvement of the RhoA and Akt/GSK3β signaling pathways. Park JH, et al. PLoS One, 2014. PMID 25268128, Free PMC Article
  3. Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis. Liu CA, et al. Oncogene, 2004 Nov 18. PMID 15480428
  4. MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma. Zhou J, et al. Oncol Rep, 2017 Feb. PMID 27922690
  5. The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. Reynaud C, et al. J Biol Chem, 2000 Oct 27. PMID 10940294

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rhotekin is required for maintenance and survival of neurons and positively regulates differentiation and neurite outgrowth.
    Title: Rhotekin modulates differentiation of cultured neural stem cells to neurons.
  2. SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling
    Title: SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actomyosin contractile ring assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in septin ring organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rhotekin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415851.2 → NP_001402780.1  rhotekin isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q6V7V1, Q6V7V2
    UniProtKB/TrEMBL
    A0A8I6G5K4, A6IAK9
    Related
    ENSRNOP00000032233.3, ENSRNOT00000031964.6

  2. NM_001415852.2 → NP_001402781.1  rhotekin isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AIK7, A0A8I6G5K4
    Related
    ENSRNOP00000092765.1, ENSRNOT00000101909.2

  3. NM_001415853.2 → NP_001402782.1  rhotekin isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6G5K4
    Related
    ENSRNOP00000099265.1, ENSRNOT00000124729.1

  4. NM_001415854.2 → NP_001402783.1  rhotekin isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  5. NM_184046.3 → NP_908935.1  rhotekin isoform 1

    See identical proteins and their annotated locations for NP_908935.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q6V7V1, Q6V7V2
    UniProtKB/TrEMBL
    A0A8I6G5K4, A6IAK9
    Conserved Domains (3) summary
    smart00742
    Location:23 → 78
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam08174
    Location:104 → 257
    Anillin; Cell division protein anillin
    cl17171
    Location:296 → 406
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    117198496..117215660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285792.1 → XP_063141862.1  rhotekin isoform X5

    UniProtKB/TrEMBL
    A0A8I6G5K4

  2. XM_063285795.1 → XP_063141865.1  rhotekin isoform X7

    UniProtKB/TrEMBL
    A0A8I6G5K4

  3. XM_039107325.2 → XP_038963253.1  rhotekin isoform X4

    UniProtKB/TrEMBL
    A0A8I6G5K4
    Conserved Domains (3) summary
    pfam08174
    Location:67 → 220
    Anillin; Cell division protein anillin
    cl00087
    Location:1 → 41
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl17171
    Location:259 → 369
    PH-like; Pleckstrin homology-like domain

  4. XM_063285797.1 → XP_063141867.1  rhotekin isoform X9

  5. XM_063285794.1 → XP_063141864.1  rhotekin isoform X7

    UniProtKB/TrEMBL
    A0A8I6G5K4

  6. XM_063285793.1 → XP_063141863.1  rhotekin isoform X6

    UniProtKB/TrEMBL
    A0A8I6G5K4

  7. XM_063285796.1 → XP_063141866.1  rhotekin isoform X8

  8. XM_008763038.4 → XP_008761260.1  rhotekin isoform X3

    See identical proteins and their annotated locations for XP_008761260.1

    UniProtKB/TrEMBL
    A0A8L2UPK3
    Conserved Domains (4) summary
    smart00742
    Location:80 → 135
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam00169
    Location:377 → 455
    PH; PH domain
    pfam08174
    Location:161 → 314
    Anillin; Cell division protein anillin
    cl17171
    Location:353 → 463
    PH-like; Pleckstrin homology-like domain

  9. XM_008763037.4 → XP_008761259.1  rhotekin isoform X2

    See identical proteins and their annotated locations for XP_008761259.1

    UniProtKB/TrEMBL
    A0A8L2UPK3
    Conserved Domains (4) summary
    smart00742
    Location:80 → 135
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam00169
    Location:307 → 385
    PH; PH domain
    pfam08174
    Location:161 → 244
    Anillin; Cell division protein anillin
    cl17171
    Location:283 → 393
    PH-like; Pleckstrin homology-like domain

  10. XM_008763034.4 → XP_008761256.1  rhotekin isoform X1

    See identical proteins and their annotated locations for XP_008761256.1

    UniProtKB/TrEMBL
    A0A8L2UPK3
    Related
    ENSRNOP00000069449.3, ENSRNOT00000079547.3
    Conserved Domains (4) summary
    smart00742
    Location:80 → 135
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam00169
    Location:377 → 455
    PH; PH domain
    pfam08174
    Location:161 → 314
    Anillin; Cell division protein anillin
    cl17171
    Location:353 → 463
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6V7V2.1 GenPept UniProtKB/Swiss-Prot:Q6V7V2

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