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Atp5mc1 ATP synthase membrane subunit c locus 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29754, updated on 4-Jan-2025

Summary

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Official Symbol
Atp5mc1provided by RGD
Official Full Name
ATP synthase membrane subunit c locus 1provided by RGD
Primary source
RGD:61933
See related
EnsemblRapid:ENSRNOG00000007235 AllianceGenome:RGD:61933
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp5g1
Summary
Enables ligand-gated channel activity. Involved in several processes, including cellular response to L-glutamate; cold acclimation; and negative regulation of mitochondrial membrane potential. Located in distal axon and neuronal cell body. Part of proton-transporting ATP synthase complex, coupling factor F(o). Orthologous to human ATP5MC1 (ATP synthase membrane subunit c locus 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 4869.4), Muscle (RPKM 2859.4) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atp5mc1 in Genome Data Viewer
Location:
10q26
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (81520762..81523735, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (81024056..81026780, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (83895941..83898640, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene high mobility group protein B1-like Neighboring gene SNF8 subunit of ESCRT-II Neighboring gene ubiquitin-conjugating enzyme E2Z Neighboring gene calcium binding and coiled-coil domain 2 Neighboring gene tubulin tyrosine ligase like 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity. Park HA, et al. Cell Death Differ, 2017 Nov. PMID 28777375, Free PMC Article
  2. Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition. Bonora M, et al. Cell Cycle, 2013 Feb 15. PMID 23343770, Free PMC Article
  3. Local translation of ATP synthase subunit 9 mRNA alters ATP levels and the production of ROS in the axon. Natera-Naranjo O, et al. Mol Cell Neurosci, 2012 Mar. PMID 22209705
  4. MicroRNA-338 regulates the axonal expression of multiple nuclear-encoded mitochondrial mRNAs encoding subunits of the oxidative phosphorylation machinery. Aschrafi A, et al. Cell Mol Life Sci, 2012 Dec. PMID 22773120, Free PMC Article
  5. Batten disease and the control of the Fo subunit c pore by cGMP and calcium. McGeoch JE, et al. Eur J Paediatr Neurol, 2001. PMID 11588987

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that microRNA-338 (miR-338) modulation of local cytochrome c oxidase IV (COXIV) and ATP synthase subunit 9 (ATP5G1) expression has a marked effect on axonal reactive oxygen species levels, as well as axonal growth.
    Title: MicroRNA-338 regulates the axonal expression of multiple nuclear-encoded mitochondrial mRNAs encoding subunits of the oxidative phosphorylation machinery.
  2. The c subunit of the F0 ATP synthase constitutes a critical component of the mitochondrial permeability transition pore.
    Title: Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition.
  3. The siRNA-mediated knock-down of axonal ATP5G1 mRNA resulted in a significant reduction of axonal ATP5G1 protein and ATP levels. Silencing of local ATP5G1 expression enhanced the production of local reactive oxygen species.
    Title: Local translation of ATP synthase subunit 9 mRNA alters ATP levels and the production of ROS in the axon.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ligand-gated channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to L-glutamate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cold acclimation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pore complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to 3,3',5-triiodo-L-thyronine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of cation channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in distal axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proton-transporting ATP synthase complex, coupling factor F(o) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ATP synthase F(0) complex subunit C1, mitochondrial
Names
ATP synthase H+ transporting mitochondrial F0 complex subunit c (subunit 9)
ATP synthase lipid-binding protein, mitochondrial
ATP synthase proteolipid P1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
ATPase protein 9
ATPase subunit c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017311.1 → NP_059007.1  ATP synthase F(0) complex subunit C1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_059007.1

    Status: PROVISIONAL

    Source sequence(s)
    D13123
    UniProtKB/Swiss-Prot
    Q06645
    UniProtKB/TrEMBL
    A6HID1
    Related
    ENSRNOP00000108669.1, ENSRNOT00000009815.7
    Conserved Domains (1) summary
    MTH00222
    Location:62 → 136
    ATP9; ATP synthase F0 subunit 9; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    81520762..81523735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247188.5 → XP_006247250.1  ATP synthase F(0) complex subunit C1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006247250.1

    UniProtKB/Swiss-Prot
    Q06645
    UniProtKB/TrEMBL
    A6HID1
    Conserved Domains (1) summary
    MTH00222
    Location:62 → 136
    ATP9; ATP synthase F0 subunit 9; Provisional

  2. XM_006247189.3 → XP_006247251.1  ATP synthase F(0) complex subunit C1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006247251.1

    UniProtKB/Swiss-Prot
    Q06645
    UniProtKB/TrEMBL
    A6HID1
    Conserved Domains (1) summary
    MTH00222
    Location:62 → 136
    ATP9; ATP synthase F0 subunit 9; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06645.1 GenPept UniProtKB/Swiss-Prot:Q06645

Gene LinkOut

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