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Dsel dermatan sulfate epimerase-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 297865, updated on 27-Nov-2024

Summary

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Official Symbol
Dselprovided by RGD
Official Full Name
dermatan sulfate epimerase-likeprovided by RGD
Primary source
RGD:1307724
See related
EnsemblRapid:ENSRNOG00000032307 AllianceGenome:RGD:1307724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307724
Summary
Predicted to enable chondroitin-glucuronate 5-epimerase activity. Predicted to be involved in chondroitin sulfate metabolic process and dermatan sulfate metabolic process. Predicted to be located in membrane. Orthologous to human DSEL (dermatan sulfate epimerase like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 58.5), Brain (RPKM 52.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dsel in Genome Data Viewer
Location:
13p13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (194738..200959, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (186413..192592, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (1942384..1948563, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene pyruvate kinase M1/2, pseudogene 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein S3a, pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mouse development is not obviously affected by the absence of dermatan sulfate epimerase 2 in spite of a modified brain dermatan sulfate composition. Bartolini B, et al. Glycobiology, 2012 Jul. PMID 22496542
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chondroitin-glucuronate 5-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chondroitin-glucuronate 5-epimerase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chondroitin sulfate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chondroitin sulfate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dermatan sulfate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dermatan sulfate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dermatan-sulfate epimerase-like protein
XP_006249670.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429578.1 → NP_001416507.1  dermatan-sulfate epimerase-like protein precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6K6R8, D3ZYE3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    194738..200959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249608.5 → XP_006249670.1  dermatan-sulfate epimerase-like protein isoform X1

    Related
    ENSRNOP00000111063.1, ENSRNOT00000156385.1
    Conserved Domains (1) summary
    cl21551
    Location:1007 → 1154
    Sulfotransfer_1; Sulfotransferase domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001305281.1: Suppressed sequence

    Description
    NM_001305281.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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