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Sytl1 synaptotagmin-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297872, updated on 27-Nov-2024

Summary

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Official Symbol
Sytl1provided by RGD
Official Full Name
synaptotagmin-like 1provided by RGD
Primary source
RGD:1310715
See related
EnsemblRapid:ENSRNOG00000008600 AllianceGenome:RGD:1310715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Slp-1
Summary
Predicted to enable neurexin family protein binding activity. Predicted to be involved in exocytosis. Predicted to be located in melanosome and membrane. Predicted to be active in exocytic vesicle and plasma membrane. Orthologous to human SYTL1 (synaptotagmin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 64.0), Lung (RPKM 28.2) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sytl1 in Genome Data Viewer
Location:
5q36
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (150736425..150746840, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145452524..145462940, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151448639..151459870, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene CD164 molecule like 2 Neighboring gene mitogen-activated protein kinase kinase kinase 6 Neighboring gene transmembrane protein 222 Neighboring gene uncharacterized LOC134487005 Neighboring gene WD and tetratricopeptide repeats 1 Neighboring gene uncharacterized LOC134487006

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Arimura N, et al. Dev Cell, 2009 May. PMID 19460344
  2. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. Holt O, et al. Traffic, 2008 Apr. PMID 18266782, Free PMC Article
  3. Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. Fukuda M, et al. Biochem Biophys Res Commun, 2001 Mar. PMID 11243866
  4. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. Kuroda TS, et al. J Biol Chem, 2002 Mar 15. PMID 11773082
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112642

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables neurexin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neurexin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in melanosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
synaptotagmin-like protein 1
Names
exophilin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025651.1 → NP_001020822.1  synaptotagmin-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001020822.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098679
    UniProtKB/TrEMBL
    A0A0G2K2R4, A6ISW2, Q4KMA1
    Related
    ENSRNOP00000061610.1, ENSRNOT00000064472.4
    Conserved Domains (4) summary
    cd04020
    Location:399 → 517
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    pfam05466
    Location:121 → 229
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl14603
    Location:267 → 386
    C2; C2 domain
    cl22851
    Location:35 → 99
    PHD_SF; PHD finger superfamily

  2. NM_001399037.1 → NP_001385966.1  synaptotagmin-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    Related
    ENSRNOP00000072343.2, ENSRNOT00000087836.3
    Conserved Domains (3) summary
    cd04020
    Location:399 → 555
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:267 → 386
    C2; C2 domain
    cl22851
    Location:35 → 90
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    150736425..150746840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109413.2 → XP_038965341.1  synaptotagmin-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2R4, A6ISW2
    Conserved Domains (3) summary
    cd04020
    Location:399 → 555
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:267 → 386
    C2; C2 domain
    cl22851
    Location:35 → 90
    PHD_SF; PHD finger superfamily
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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