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Ndrg2 N-myc downstream regulated gene 2 [ Mus musculus (house mouse) ]

Gene ID: 29811, updated on 27-Nov-2024

Summary

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Official Symbol
Ndrg2provided by MGI
Official Full Name
N-myc downstream regulated gene 2provided by MGI
Primary source
MGI:MGI:1352498
See related
Ensembl:ENSMUSG00000004558 AllianceGenome:MGI:1352498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ndr2; SYLD
Summary
Acts upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of vascular associated smooth muscle cell proliferation; and regulation of cytokine production. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and sensory organ. Orthologous to human NDRG2 (NDRG family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver adult (RPKM 416.8), heart adult (RPKM 317.4) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Ndrg2 in Genome Data Viewer
Location:
14 C2; 14 26.72 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52142738..52151463, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51905271..51914004, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 17 Neighboring gene solute carrier family 39 (zinc transporter), member 2 Neighboring gene tubulin polymerization-promoting protein family member 2 Neighboring gene ribonuclease, RNase A family, 13 (non-active)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NDRG2 alleviates photoreceptor apoptosis by regulating the STAT3/TIMP3/MMP pathway in mice with retinal degenerative disease. Chen T, et al. FEBS J, 2024 Mar. PMID 38037211
  2. Immunohistochemical detection of Ndrg2 in the mouse nervous system. Shen L, et al. Neuroreport, 2008 Jun 11. PMID 18520995
  3. Electroacupuncture attenuates reference memory impairment associated with astrocytic NDRG2 suppression in APP/PS1 transgenic mice. Wang F, et al. Mol Neurobiol, 2014 Oct. PMID 24390566
  4. Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury. Takarada-Iemata M, et al. J Neurochem, 2014 Aug. PMID 24697507
  5. Uterine NDRG2 expression is increased at implantation sites during early pregnancy in mice, and its down-regulation inhibits decidualization of mouse endometrial stromal cells. Gu Y, et al. Reprod Biol Endocrinol, 2015 May 27. PMID 26013399, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NDRG2 regulates glucose metabolism and ferroptosis of OGD/R-treated astrocytes by the Wnt/beta-catenin signaling.
    Title: NDRG2 regulates glucose metabolism and ferroptosis of OGD/R-treated astrocytes by the Wnt/β-catenin signaling.
  2. NDRG2 alleviates photoreceptor apoptosis by regulating the STAT3/TIMP3/MMP pathway in mice with retinal degenerative disease.
    Title: NDRG2 alleviates photoreceptor apoptosis by regulating the STAT3/TIMP3/MMP pathway in mice with retinal degenerative disease.
  3. Reprogramming astrocytic NDRG2/NF-kappaB/C3 signaling restores the diabetes-associated cognitive dysfunction.
    Title: Reprogramming astrocytic NDRG2/NF-κB/C3 signaling restores the diabetes-associated cognitive dysfunction.
  4. ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis.
    Title: ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis.
  5. Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.
    Title: Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.
  6. N-myc Downstream-Regulated Gene 2 (Ndrg2): A Critical Mediator of Estrogen-Induced Neuroprotection Against Cerebral Ischemic Injury.
    Title: N-myc Downstream-Regulated Gene 2 (Ndrg2): A Critical Mediator of Estrogen-Induced Neuroprotection Against Cerebral Ischemic Injury.
  7. Transcription factor Kruppel-like factor 5-regulated N-myc downstream-regulated gene 2 reduces IL-1beta-induced chondrocyte inflammatory injury and extracellular matrix degradation.
    Title: Transcription factor Krüppel-like factor 5-regulated N-myc downstream-regulated gene 2 reduces IL-1β-induced chondrocyte inflammatory injury and extracellular matrix degradation.
  8. Long noncoding RNA MIR22HG promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-125a-5p that targets N-Myc downstream-regulated gene 2 in late-onset hypogonadism.
    Title: Long noncoding RNA MIR22HG promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-125a-5p that targets N-Myc downstream-regulated gene 2 in late-onset hypogonadism.
  9. Overexpression of NDRG2 in skeletal muscle does not ameliorate the effects of stress in vivo.
    Title: Overexpression of NDRG2 in skeletal muscle does not ameliorate the effects of stress in vivo.
  10. NDRG2 is expressed on enteric glia and altered in conditions of inflammation and oxygen glucose deprivation/reoxygenation.
    Title: NDRG2 is expressed on enteric glia and altered in conditions of inflammation and oxygen glucose deprivation/reoxygenation.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of platelet-derived growth factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein NDRG2
Names
N-myc downstream regulated 2
N-myc downstream-regulated gene 2 protein
protein Ndr2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145959.2 → NP_001139431.1  protein NDRG2 isoform 2

    See identical proteins and their annotated locations for NP_001139431.1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS49486.1
    UniProtKB/Swiss-Prot
    Q9QYG0
    Related
    ENSMUSP00000107259.4, ENSMUST00000111632.5
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  2. NM_001360264.2 → NP_001347193.1  protein NDRG2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Conserved Domains (1) summary
    pfam03096
    Location:43 → 321
    Ndr; Ndr family

  3. NM_001360265.2 → NP_001347194.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

  4. NM_001360266.2 → NP_001347195.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

  5. NM_001360267.2 → NP_001347196.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

  6. NM_001360268.2 → NP_001347197.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

  7. NM_001360269.2 → NP_001347198.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

  8. NM_001360270.2 → NP_001347199.1  protein NDRG2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Conserved Domains (1) summary
    pfam03096
    Location:29 → 307
    Ndr; Ndr family

  9. NM_001360271.2 → NP_001347200.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS49486.1
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  10. NM_001360272.2 → NP_001347201.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS49486.1
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  11. NM_001360273.2 → NP_001347202.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS49486.1
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  12. NM_001360274.2 → NP_001347203.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS49486.1
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  13. NM_001360276.2 → NP_001347205.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS49486.1
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  14. NM_001424691.1 → NP_001411620.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087

  15. NM_001424692.1 → NP_001411621.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087

  16. NM_001424693.1 → NP_001411622.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087

  17. NM_001424694.1 → NP_001411623.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087

  18. NM_001424695.1 → NP_001411624.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0

  19. NM_001424696.1 → NP_001411625.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0

  20. NM_001424697.1 → NP_001411626.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0

  21. NM_001424698.1 → NP_001411627.1  protein NDRG2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC125087

  22. NM_001424699.1 → NP_001411628.1  protein NDRG2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC125087

  23. NM_001424700.1 → NP_001411629.1  protein NDRG2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC125087

  24. NM_001424701.1 → NP_001411630.1  protein NDRG2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC125087

  25. NM_013864.3 → NP_038892.1  protein NDRG2 isoform 1

    See identical proteins and their annotated locations for NP_038892.1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Related
    ENSMUSP00000004673.8, ENSMUST00000004673.15
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    52142738..52151463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158660.1 → XP_036014553.1  protein NDRG2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

  2. XM_036158662.1 → XP_036014555.1  protein NDRG2 isoform X2

    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYG0.1 GenPept UniProtKB/Swiss-Prot:Q9QYG0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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