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Tenm1 teneurin transmembrane protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298168, updated on 9-Dec-2024

Summary

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Symbol
Tenm1provided by RGD
Full Name
teneurin transmembrane protein 1provided by RGD
Primary source
RGD:1561678
See related
EnsemblRapid:ENSRNOG00000062454 AllianceGenome:RGD:1561678
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Odz1; RGD1561678
Summary
Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in positive regulation of cellular component biogenesis; positive regulation of protein phosphorylation; and regulation of transcription by RNA polymerase III. Predicted to be located in several cellular components, including extracellular region; nucleus; and perinuclear region of cytoplasm. Orthologous to human TENM1 (teneurin transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 135.8), Thymus (RPKM 63.6) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tenm1 in Genome Data Viewer
Location:
Xq35
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (126265968..127155737, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (121400466..122289877, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (129034755..129336023, complement) , (128923951..128951520, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene estrogen receptor binding site associated, antigen, 9, pseudogene 1 Neighboring gene testis-expressed protein 13D-like Neighboring gene SH2 domain containing 1A Neighboring gene small nucleolar RNA SNORA17 Neighboring gene 60S ribosomal protein L23 pseudogene Neighboring gene uncharacterized LOC134484114 Neighboring gene mitochondrial ribosomal protein S36 like 1 Neighboring gene TEX13 family member C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells. Chand D, et al. Mol Cell Neurosci, 2013 Jan. PMID 23026563
  2. Repeated intracerebral teneurin C-terminal associated peptide (TCAP)-1 injections produce enduring changes in behavioral responses to corticotropin-releasing factor (CRF) in rat models of anxiety. Tan LA, et al. Behav Brain Res, 2008 Mar 17. PMID 18082275
  3. C-Terminal region of teneurin-1 co-localizes with dystroglycan and modulates cytoskeletal organization through an extracellular signal-regulated kinase-dependent stathmin- and filamin A-mediated mechanism in hippocampal cells. Chand D, et al. Neuroscience, 2012 Sep 6. PMID 22698694
  4. Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells. Ng T, et al. Regul Pept, 2012 Feb 10. PMID 22209827
  5. Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues. Oohashi T, et al. J Cell Biol, 1999 May 3. PMID 10225957, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the plus maze and open field tests, acute CRF effects were enhanced by prior TCAP-1 treatment, whereas in the acoustic startle test, the acute CRF effects were diminished by prior TCAP-1 administration [TCAP-1]
    Title: Repeated intracerebral teneurin C-terminal associated peptide (TCAP)-1 injections produce enduring changes in behavioral responses to corticotropin-releasing factor (CRF) in rat models of anxiety.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
teneurin-1
Names
protein Odd Oz/ten-m homolog 1
teneurin-1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    126265968..127155737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280507.1 → XP_063136577.1  teneurin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQ34

  2. XM_063280510.1 → XP_063136580.1  teneurin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQ34

  3. XM_039100433.2 → XP_038956361.1  teneurin-1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AQ34
    Related
    ENSRNOP00000100767.1, ENSRNOT00000135707.1
    Conserved Domains (9) summary
    COG3209
    Location:1823 → 2392
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1195 → 1234
    NHL; NHL repeat [structural motif]
    cl18310
    Location:1195 → 1526
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1642 → 1674
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23 → 317
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2646 → 2723
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033662
    Location:801 → 826
    acid_disulf_rpt; acidic double-disulfide repeat
    NF033759
    Location:533 → 741
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:709 → 750
    DSL; Delta serrate ligand

  4. XM_063280511.1 → XP_063136581.1  teneurin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQ34

  5. XM_039100429.2 → XP_038956357.1  teneurin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y571, A0A8I6AQ34
    Related
    ENSRNOP00000076979.1, ENSRNOT00000100607.2
    Conserved Domains (9) summary
    COG3209
    Location:1824 → 2393
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1196 → 1235
    NHL; NHL repeat [structural motif]
    cl18310
    Location:1196 → 1527
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1643 → 1675
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23 → 317
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2647 → 2724
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033662
    Location:802 → 827
    acid_disulf_rpt; acidic double-disulfide repeat
    NF033759
    Location:534 → 742
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:710 → 751
    DSL; Delta serrate ligand

  6. XM_063280506.1 → XP_063136576.1  teneurin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQ34
    Related
    ENSRNOP00000104343.1, ENSRNOT00000143389.1

  7. XM_063280509.1 → XP_063136579.1  teneurin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQ34

  8. XM_063280508.1 → XP_063136578.1  teneurin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQ34
Nucleotide Protein Strain
Heading Accession and Version

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