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Rad54l RAD54 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 298429, updated on 4-Jan-2025

Summary

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Official Symbol
Rad54lprovided by RGD
Official Full Name
RAD54 likeprovided by RGD
Primary source
RGD:1310600
See related
EnsemblRapid:ENSRNOG00000013148 AllianceGenome:RGD:1310600
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP-dependent DNA/DNA annealing activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within several processes, including determination of adult lifespan; double-strand break repair via homologous recombination; and response to ionizing radiation. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in breast cancer; disease of cellular proliferation; non-Hodgkin lymphoma; and pancreatic cancer. Orthologous to human RAD54L (RAD54 like). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 79.1), Spleen (RPKM 48.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rad54l in Genome Data Viewer
Location:
5q35
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134812158..134841821, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129575431..129605100, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (134948511..134978125, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene uncharacterized LOC134486970 Neighboring gene leucine rich repeat containing 41 Neighboring gene uncharacterized LOC134486969 Neighboring gene leucine rich adaptor protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in the RAD54 recombination gene in primary cancers. Matsuda M, et al. Oncogene, 1999 Jun 3. PMID 10362365
  2. Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Mills KD, et al. Genes Dev, 2004 Jun 1. PMID 15175260, Free PMC Article
  3. Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1α/VEGF signaling pathway: Bioinformatics analysis and experimental validation. Li Z, et al. PLoS One, 2024. PMID 38593124, Free PMC Article
  4. Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair. Kirshner M, et al. DNA Repair (Amst), 2009 Feb 1. PMID 19061978
  5. Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation. Wang H, et al. Nucleic Acids Res, 2010 Jun. PMID 20150414, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1alpha/VEGF signaling pathway: Bioinformatics analysis and experimental validation.
    Title: Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1α/VEGF signaling pathway: Bioinformatics analysis and experimental validation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC189414

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA/DNA annealing activity ISO
Inferred from Sequence Orthology
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA repair and recombination protein RAD54-like
NP_001128432.1
XP_038965522.1
XP_063143472.1
XP_063143473.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134960.1 → NP_001128432.1  DNA repair and recombination protein RAD54-like

    See identical proteins and their annotated locations for NP_001128432.1

    Status: PROVISIONAL

    Source sequence(s)
    BC169034
    UniProtKB/TrEMBL
    A0A8I6AKM5, B5DFE8
    Conserved Domains (4) summary
    cd00046
    Location:177 → 327
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:490 → 619
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:156 → 463
    SNF2_N; SNF2 family N-terminal domain
    pfam08658
    Location:74 → 123
    Rad54_N; Rad54 N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    134812158..134841821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287402.1 → XP_063143472.1  DNA repair and recombination protein RAD54-like isoform X1

    UniProtKB/TrEMBL
    A0A8I6AKM5, B5DFE8
    Related
    ENSRNOP00000018004.7, ENSRNOT00000018004.7

  2. XM_039109594.1 → XP_038965522.1  DNA repair and recombination protein RAD54-like isoform X2

    Conserved Domains (2) summary
    cd18067
    Location:153 → 395
    DEXHc_RAD54A; DEXH-box helicase domain of RAD54A
    pfam08658
    Location:76 → 123
    Rad54_N; Rad54 N terminal

  3. XM_063287403.1 → XP_063143473.1  DNA repair and recombination protein RAD54-like isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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