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Dmap1 DNA methyltransferase 1-associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298447, updated on 27-Nov-2024

Summary

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Official Symbol
Dmap1provided by RGD
Official Full Name
DNA methyltransferase 1-associated protein 1provided by RGD
Primary source
RGD:1311295
See related
EnsemblRapid:ENSRNOG00000019407 AllianceGenome:RGD:1311295
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in response to ethanol. Predicted to be located in cytosol; nucleoplasm; and replication fork. Predicted to be part of NuA4 histone acetyltransferase complex; Swr1 complex; and nucleosome. Orthologous to human DMAP1 (DNA methyltransferase 1 associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 101.3), Thymus (RPKM 97.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dmap1 in Genome Data Viewer
Location:
5q36
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (136380211..136388229, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (131143726..131151760, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (136533791..136541795, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486975 Neighboring gene ERI1 exoribonuclease family member 3 Neighboring gene iron-sulfur cluster assembly 1 homolog, mitochondrial-like Neighboring gene uncharacterized LOC134486976 Neighboring gene uncharacterized LOC102553953

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. Echeverry-Alzate V, et al. Br J Pharmacol, 2014 Jun. PMID 24527678, Free PMC Article
  2. Subcellular localization of RPB5-mediating protein and its putative functional partner. Delgermaa L, et al. Mol Cell Biol, 2004 Oct. PMID 15367675, Free PMC Article
  3. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Rountree MR, et al. Nat Genet, 2000 Jul. PMID 10888872
  4. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417
  5. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Doyon Y, et al. Mol Cell Biol, 2004 Mar. PMID 14966270, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC109435

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in replication fork ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA methyltransferase 1-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015006.1 → NP_001015006.1  DNA methyltransferase 1-associated protein 1

    See identical proteins and their annotated locations for NP_001015006.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092651
    UniProtKB/TrEMBL
    A0A8I6A1B5, F7FQE3, Q568Y6
    Related
    ENSRNOP00000026336.4, ENSRNOT00000026336.7
    Conserved Domains (2) summary
    pfam05499
    Location:243 → 402
    DMAP1; DNA methyltransferase 1-associated protein 1 (DMAP1)
    pfam16282
    Location:124 → 203
    SANT_DAMP1_like; SANT/Myb-like domain of DAMP1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    136380211..136388229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109606.2 → XP_038965534.1  DNA methyltransferase 1-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A1B5, F7FQE3, Q568Y6
    Conserved Domains (2) summary
    pfam05499
    Location:243 → 402
    DMAP1; DNA methyltransferase 1-associated protein 1 (DMAP1)
    pfam16282
    Location:124 → 203
    SANT_DAMP1_like; SANT/Myb-like domain of DAMP1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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