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Pla2g2d phospholipase A2, group IID [ Rattus norvegicus (Norway rat) ]

Gene ID: 298579, updated on 4-Jan-2025

Summary

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Official Symbol
Pla2g2dprovided by RGD
Official Full Name
phospholipase A2, group IIDprovided by RGD
Primary source
RGD:1309862
See related
EnsemblRapid:ENSRNOG00000016826 AllianceGenome:RGD:1309862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including calcium-dependent phospholipase A2 activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to be involved in glycerophospholipid metabolic process; negative regulation of T cell proliferation; and regulation of acute inflammatory response to antigenic stimulus. Predicted to act upstream of or within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation and negative regulation of T cell activation. Predicted to be located in extracellular region. Orthologous to human PLA2G2D (phospholipase A2 group IID). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 252.0), Lung (RPKM 176.1) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Pla2g2d in Genome Data Viewer
Location:
5q36
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (156299374..156305816)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151016010..151022531)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (157222636..157228795)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene UBX domain protein 10 Neighboring gene phospholipase A2, group IIC Neighboring gene phospholipase A2, group IIF Neighboring gene phospholipase A2, group V Neighboring gene phospholipase A2 group IIA Neighboring gene phospholipase A2, group IIE

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells. von Allmen CE, et al. Proc Natl Acad Sci U S A, 2009 Jul 14. PMID 19564598, Free PMC Article
  2. Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. Suzuki N, et al. J Biol Chem, 2000 Feb 25. PMID 10681567
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108956

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
enables heparan sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in arachidonate secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of acute inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
group IID secretory phospholipase A2
NP_001013446.1
XP_038965606.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013428.2 → NP_001013446.1  group IID secretory phospholipase A2 precursor

    See identical proteins and their annotated locations for NP_001013446.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    F7F420, Q5BK35
    Related
    ENSRNOP00000112008.1, ENSRNOT00000130250.1
    Conserved Domains (1) summary
    cd00125
    Location:20 → 137
    PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    156299374..156305816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109678.2 → XP_038965606.1  group IID secretory phospholipase A2 isoform X1

    Related
    ENSRNOP00000022579.6, ENSRNOT00000022579.7
    Conserved Domains (1) summary
    cd00125
    Location:1 → 111
    PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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