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Igsf21 immunoglobin superfamily, member 21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298591, updated on 4-Jan-2025

Summary

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Symbol
Igsf21provided by RGD
Full Name
immunoglobin superfamily, member 21provided by RGD
Primary source
RGD:1310117
See related
EnsemblRapid:ENSRNOG00000049959 AllianceGenome:RGD:1310117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310117
Summary
Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules; synapse maturation; and trans-synaptic signaling, modulating synaptic transmission. Predicted to be located in external side of plasma membrane and inhibitory synapse. Predicted to be active in postsynaptic density membrane and presynaptic membrane. Orthologous to human IGSF21 (immunoglobin superfamily member 21). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 42.2) See more
Orthologs
human mouse all
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Genomic context

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See Igsf21 in Genome Data Viewer
Location:
5q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (157570964..157795290, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (152287834..152512174, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (158503090..158735702, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like Neighboring gene kelch domain containing 7A Neighboring gene uncharacterized LOC134487088 Neighboring gene uncharacterized LOC134479044

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α. Tanabe Y, et al. Nat Commun, 2017 Sep 1. PMID 28864826, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in trans-synaptic signaling, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in trans-synaptic signaling, modulating synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in inhibitory synapse IEA
Inferred from Electronic Annotation
more info
  
located_in inhibitory synapse ISO
Inferred from Sequence Orthology
more info
  
located_in inhibitory synapse ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
immunoglobulin superfamily member 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271454.2 → NP_001258383.1  immunoglobulin superfamily member 21 precursor

    See identical proteins and their annotated locations for NP_001258383.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    M0RAS4
    UniProtKB/TrEMBL
    A6ITN5
    Related
    ENSRNOP00000066631.3, ENSRNOT00000074336.4
    Conserved Domains (1) summary
    cl11960
    Location:372 → 432
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    157570964..157795290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109686.2 → XP_038965614.1  immunoglobulin superfamily member 21 isoform X2

    Conserved Domains (2) summary
    cd00096
    Location:178 → 182
    Ig; Ig strand C [structural motif]
    cl11960
    Location:175 → 235
    Ig; Immunoglobulin domain

  2. XM_039109685.2 → XP_038965613.1  immunoglobulin superfamily member 21 isoform X1

    Related
    ENSRNOP00000107300.1, ENSRNOT00000141290.1
    Conserved Domains (2) summary
    cd00096
    Location:332 → 336
    Ig; Ig strand C [structural motif]
    cl11960
    Location:329 → 389
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M0RAS4.3 GenPept UniProtKB/Swiss-Prot:M0RAS4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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