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Ube2j2 ubiquitin-conjugating enzyme E2, J2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298689, updated on 4-Jan-2025

Summary

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Official Symbol
Ube2j2provided by RGD
Official Full Name
ubiquitin-conjugating enzyme E2, J2provided by RGD
Primary source
RGD:1359523
See related
EnsemblRapid:ENSRNOG00000019749 AllianceGenome:RGD:1359523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of protein targeting to mitochondrion; protein K6-linked ubiquitination; and proteolysis involved in protein catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in endoplasmic reticulum and nucleus. Orthologous to human UBE2J2 (ubiquitin conjugating enzyme E2 J2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 159.3), Thymus (RPKM 155.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ube2j2 in Genome Data Viewer
Location:
5q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171815607..171830037)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166533374..166547811)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173372659..173387084)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Neighboring gene sodium channel epithelial 1 delta subunit Neighboring gene C1q and TNF related 12 Neighboring gene uncharacterized LOC134487051 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). Tiwari S, et al. J Biol Chem, 2001 May 11. PMID 11278356
  2. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. van de Weijer ML, et al. Nat Commun, 2014 May 8. PMID 24807418, Free PMC Article
  3. RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR). El Khouri E, et al. J Biol Chem, 2013 Oct 25. PMID 24019521, Free PMC Article
  4. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. David Y, et al. J Biol Chem, 2010 Mar 19. PMID 20061386, Free PMC Article
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94113

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 J2
Names
ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)
NP_001007656.2
XP_006239616.1
XP_006239617.1
XP_006239619.1
XP_006239620.1
XP_008762577.1
XP_063143577.1
XP_063143578.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007655.2 → NP_001007656.2  ubiquitin-conjugating enzyme E2 J2

    See identical proteins and their annotated locations for NP_001007656.2

    Status: VALIDATED

    Source sequence(s)
    BC079115, JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K8C5, A0A8J8XLZ8, A6IUU4
    Conserved Domains (1) summary
    cd00195
    Location:26 → 139
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    171815607..171830037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287508.1 → XP_063143578.1  ubiquitin-conjugating enzyme E2 J2 isoform X3

  2. XM_006239558.5 → XP_006239620.1  ubiquitin-conjugating enzyme E2 J2 isoform X2

    See identical proteins and their annotated locations for XP_006239620.1

    UniProtKB/TrEMBL
    A0A8J8XLZ8, G3V8L8, Q6AYB7
    Conserved Domains (1) summary
    cd00195
    Location:14 → 127
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. XM_063287507.1 → XP_063143577.1  ubiquitin-conjugating enzyme E2 J2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8C5, A0A8J8XLZ8, A6IUU4
    Related
    ENSRNOP00000074553.1, ENSRNOT00000077602.3

  4. XM_006239555.5 → XP_006239617.1  ubiquitin-conjugating enzyme E2 J2 isoform X1

    See identical proteins and their annotated locations for XP_006239617.1

    UniProtKB/TrEMBL
    A0A0G2K8C5, A0A8J8XLZ8, A6IUU4
    Conserved Domains (1) summary
    cd00195
    Location:26 → 139
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  5. XM_006239557.5 → XP_006239619.1  ubiquitin-conjugating enzyme E2 J2 isoform X2

    See identical proteins and their annotated locations for XP_006239619.1

    UniProtKB/TrEMBL
    A0A8J8XLZ8, G3V8L8, Q6AYB7
    Conserved Domains (1) summary
    cd00195
    Location:14 → 127
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  6. XM_006239554.5 → XP_006239616.1  ubiquitin-conjugating enzyme E2 J2 isoform X1

    See identical proteins and their annotated locations for XP_006239616.1

    UniProtKB/TrEMBL
    A0A0G2K8C5, A0A8J8XLZ8, A6IUU4
    Conserved Domains (1) summary
    cd00195
    Location:26 → 139
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  7. XM_008764355.4 → XP_008762577.1  ubiquitin-conjugating enzyme E2 J2 isoform X2

    See identical proteins and their annotated locations for XP_008762577.1

    UniProtKB/TrEMBL
    A0A8J8XLZ8, G3V8L8, Q6AYB7
    Related
    ENSRNOP00000026752.7, ENSRNOT00000026752.9
    Conserved Domains (1) summary
    cd00195
    Location:14 → 127
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein Strain
Heading Accession and Version

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