Kcnf1 potassium voltage-gated channel modifier subfamily F member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnf1provided by RGD
Official Full Name: potassium voltage-gated channel modifier subfamily F member 1provided by RGD
Primary source: RGD:631414
See related: EnsemblRapid:ENSRNOG00000024310 AllianceGenome:RGD:631414
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kh1; Kv5.1
Summary: Enables potassium channel regulator activity. Involved in potassium ion transport and regulation of potassium ion transport. Part of voltage-gated potassium channel complex. Orthologous to human KCNF1 (potassium voltage-gated channel modifier subfamily F member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (45691028..45693706, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (39962301..39964979, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (42471060..42473738, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in ciliary base	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: voltage-gated potassium channel regulatory subunit KCNF1

Names: potassium channel, voltage-gated modifier subfamily F, member 1; potassium voltage-gated channel, subfamily F, member 1; voltage-gated potassium channel subunit Kv5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001169104.1 → NP_001162575.1 voltage-gated potassium channel regulatory subunit KCNF1

See identical proteins and their annotated locations for NP_001162575.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

D4ADX7

UniProtKB/TrEMBL

A6HAU1

Related

ENSRNOP00000033496.4, ENSRNOT00000033327.7

Conserved Domains (4) summary

smart00225
Location:37 → 147

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:234 → 429

Ion_trans; Ion transport protein

pfam07885
Location:343 → 412

Ion_trans_2; Ion channel

cl02518
Location:37 → 138

BTB; BTB/POZ domain