Dhrs7 dehydrogenase/reductase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dhrs7provided by RGD
Official Full Name: dehydrogenase/reductase 7provided by RGD
Primary source: RGD:1565002
See related: EnsemblRapid:ENSRNOG00000005589 AllianceGenome:RGD:1565002
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565002
Summary: Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity and carbonyl reductase (NADPH) activity. Predicted to be involved in retinol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human DHRS7 (dehydrogenase/reductase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 446.4), Liver (RPKM 229.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (97068149..97083744, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (91332259..91347856, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (95522577..95541393, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH142558 (e-PCR)
- UniSTS:231805

D6Rat17 (e-PCR)
- UniSTS:118955

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables carbonyl reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dehydrogenase/reductase SDR family member 7

Names: dehydrogenase/reductase (SDR family) member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271394.1 → NP_001258323.1 dehydrogenase/reductase SDR family member 7

Status: VALIDATED

Source sequence(s)

CV080419, FM087146, JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I5ZN24, A6HC42, D4A0T8

Related

ENSRNOP00000007645.7, ENSRNOT00000007645.9

Conserved Domains (2) summary

cd05332
Location:48 → 308

11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

pfam00106
Location:52 → 250

adh_short; short chain dehydrogenase