U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfyve1 zinc finger FYVE-type containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299188, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Zfyve1provided by RGD
Official Full Name
zinc finger FYVE-type containing 1provided by RGD
Primary source
RGD:1307795
See related
EnsemblRapid:ENSRNOG00000008614 AllianceGenome:RGD:1307795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in several processes, including cellular response to starvation; lipid droplet formation; and positive regulation by host of viral genome replication. Predicted to be located in several cellular components, including autophagosome; mitochondria-associated endoplasmic reticulum membrane contact site; and omegasome. Predicted to be extrinsic component of omegasome membrane. Predicted to be active in lipid droplet. Orthologous to human ZFYVE1 (zinc finger FYVE-type containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 83.4), Testes (RPKM 74.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Zfyve1 in Genome Data Viewer
Location:
6q31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (108916062..108965231, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103184938..103234111, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107031411..107080590, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene double PHD fingers 3 Neighboring gene uncharacterized LOC134479225 Neighboring gene uncharacterized LOC134479227 Neighboring gene uncharacterized LOC134479226 Neighboring gene DDB1 and CUL4 associated factor 4 Neighboring gene uncharacterized LOC102547293 Neighboring gene RNA binding motif protein 25 Neighboring gene presenilin 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Hayashi-Nishino M, et al. Nat Cell Biol, 2009 Dec. PMID 19898463
  2. Cellular localization and tissue distribution of endogenous DFCP1 protein. Nanao T, et al. Biomed Res, 2015. PMID 25876663
  3. DFCP1 associates with lipid droplets. Gao G, et al. Cell Biol Int, 2019 Dec. PMID 31293035
  4. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. Ridley SH, et al. J Cell Sci, 2001 Nov. PMID 11739631
  5. Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi. Cheung PC, et al. Biochem J, 2001 Apr 1. PMID 11256955, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extrinsic component of omegasome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in omegasome ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in phagophore assembly site ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger FYVE domain-containing protein 1
Names
zinc finger, FYVE domain containing 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106743.1 → NP_001100213.1  zinc finger FYVE domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001100213.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473982
    UniProtKB/TrEMBL
    A6JDQ1, D4A3T4
    Related
    ENSRNOP00000011662.5, ENSRNOT00000011662.7
    Conserved Domains (5) summary
    cd01851
    Location:174 → 410
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd15734
    Location:711 → 771
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:594 → 655
    FYVE_like_SF; FYVE domain like superfamily
    cd19819
    Location:16 → 63
    Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
    cd19820
    Location:69 → 122
    Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

  2. NM_001434296.1 → NP_001421225.1  zinc finger FYVE domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  3. NM_001434297.1 → NP_001421226.1  zinc finger FYVE domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  4. NM_001434298.1 → NP_001421227.1  zinc finger FYVE domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  5. NM_001434299.1 → NP_001421228.1  zinc finger FYVE domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    108916062..108965231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261729.1 → XP_063117799.1  zinc finger FYVE domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JDQ1, D4A3T4

  2. XM_039112024.2 → XP_038967952.1  zinc finger FYVE domain-containing protein 1 isoform X1

    Conserved Domains (5) summary
    cd01851
    Location:174 → 410
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd15734
    Location:722 → 782
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:594 → 655
    FYVE_like_SF; FYVE domain like superfamily
    cd19819
    Location:16 → 63
    Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
    cd19820
    Location:69 → 122
    Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

  3. XM_006240323.5 → XP_006240385.1  zinc finger FYVE domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JDQ1, D4A3T4
    Conserved Domains (5) summary
    cd01851
    Location:174 → 410
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd15734
    Location:711 → 771
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:594 → 655
    FYVE_like_SF; FYVE domain like superfamily
    cd19819
    Location:16 → 63
    Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
    cd19820
    Location:69 → 122
    Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

  4. XM_063261730.1 → XP_063117800.1  zinc finger FYVE domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JDQ1, D4A3T4

  5. XM_039112023.2 → XP_038967951.1  zinc finger FYVE domain-containing protein 1 isoform X1

    Conserved Domains (5) summary
    cd01851
    Location:174 → 410
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd15734
    Location:722 → 782
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:594 → 655
    FYVE_like_SF; FYVE domain like superfamily
    cd19819
    Location:16 → 63
    Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
    cd19820
    Location:69 → 122
    Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

  6. XM_039112025.2 → XP_038967953.1  zinc finger FYVE domain-containing protein 1 isoform X1

    Conserved Domains (5) summary
    cd01851
    Location:174 → 410
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd15734
    Location:722 → 782
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:594 → 655
    FYVE_like_SF; FYVE domain like superfamily
    cd19819
    Location:16 → 63
    Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
    cd19820
    Location:69 → 122
    Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

  7. XM_063261732.1 → XP_063117802.1  zinc finger FYVE domain-containing protein 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools