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Coq6 coenzyme Q6 monooxygenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 299195, updated on 4-Jan-2025

Summary

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Official Symbol
Coq6provided by RGD
Official Full Name
coenzyme Q6 monooxygenaseprovided by RGD
Primary source
RGD:1311149
See related
EnsemblRapid:ENSRNOG00000011164 AllianceGenome:RGD:1311149
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 6. Orthologous to human COQ6 (coenzyme Q6, monooxygenase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 234.9), Adrenal (RPKM 229.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Coq6 in Genome Data Viewer
Location:
6q31
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109738934..109750315)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104007814..104019888)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108076393..108087782)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene prostaglandin reductase 2 Neighboring gene zinc finger protein 410 Neighboring gene FAM161 centrosomal protein B Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 Neighboring gene basal body orientation factor 1 Neighboring gene ring finger protein 113A2 Neighboring gene aldehyde dehydrogenase 6 family, member A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in extrinsic component of mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquinone biosynthesis complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
Names
coenzyme Q10 monooxygenase 6
coenzyme Q6 homolog, monooxygenase
NP_001011983.1
XP_038967955.1
XP_038967956.1
XP_063117806.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011983.1 → NP_001011983.1  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001011983.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079342
    UniProtKB/Swiss-Prot
    Q68FU7
    UniProtKB/TrEMBL
    A6JDV5
    Related
    ENSRNOP00000014914.5, ENSRNOT00000014913.8
    Conserved Domains (2) summary
    TIGR01988
    Location:57 → 475
    Ubi-OHases; Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family
    cl21454
    Location:57 → 471
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    109738934..109750315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112028.2 → XP_038967956.1  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl21454
    Location:57 → 269
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_063261736.1 → XP_063117806.1  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial isoform X1

  3. XM_039112027.2 → XP_038967955.1  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I6AN07
    Related
    ENSRNOP00000094755.1, ENSRNOT00000107126.2
    Conserved Domains (1) summary
    cl21454
    Location:64 → 407
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FU7.1 GenPept UniProtKB/Swiss-Prot:Q68FU7

Gene LinkOut

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