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Nek9 NIMA-related kinase 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299204, updated on 27-Nov-2024

Summary

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Official Symbol
Nek9provided by RGD
Official Full Name
NIMA-related kinase 9provided by RGD
Primary source
RGD:1307187
See related
EnsemblRapid:ENSRNOG00000058572 AllianceGenome:RGD:1307187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase activator activity; protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in mitotic cell cycle and regulation of mitotic cell cycle. Predicted to be located in centrosome. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human NEK9 (NIMA related kinase 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 248.2), Muscle (RPKM 242.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nek9 in Genome Data Viewer
Location:
6q31
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110675107..110715586, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104944056..104984538, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (109121524..109162433, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene acylphosphatase 1 Neighboring gene zinc finger, C2HC-type containing 1C Neighboring gene uncharacterized LOC102549675 Neighboring gene transmembrane p24 trafficking protein 10 Neighboring gene uncharacterized LOC134479451

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. Rapley J, et al. J Cell Sci, 2008 Dec 1. PMID 19001501, Free PMC Article
  2. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. Vaz Meirelles G, et al. J Proteome Res, 2010 Dec 3. PMID 20873783
  3. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Cao Z, et al. Mol Cell Proteomics, 2008 Sep. PMID 18504258, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek9
Names
NIMA (never in mitosis gene a)- related kinase 9
NP_001100217.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106747.2 → NP_001100217.2  serine/threonine-protein kinase Nek9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AQL7, A6JE24
    Related
    ENSRNOP00000096294.1, ENSRNOT00000106509.2
    Conserved Domains (2) summary
    COG5184
    Location:344 → 687
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd08221
    Location:50 → 297
    STKc_Nek9; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    110675107..110715586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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