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Ift43 intraflagellar transport 43 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299209, updated on 4-Jan-2025

Summary

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Official Symbol
Ift43provided by RGD
Official Full Name
intraflagellar transport 43provided by RGD
Primary source
RGD:1307392
See related
EnsemblRapid:ENSRNOG00000010194 AllianceGenome:RGD:1307392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307392
Summary
Predicted to be involved in cilium assembly and intraciliary retrograde transport. Predicted to be located in centriolar satellite and centriole. Predicted to be part of intraciliary transport particle A. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in cranioectodermal dysplasia 3; retinitis pigmentosa 81; and short-rib thoracic dysplasia 18 with polydactyly. Orthologous to human IFT43 (intraflagellar transport 43). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 181.4), Testes (RPKM 160.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ift43 in Genome Data Viewer
Location:
6q31
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (111460689..111537224)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (105729734..105806257)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (109939323..110016646)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase like 5 Neighboring gene uncharacterized LOC134479235 Neighboring gene transforming growth factor, beta 3 Neighboring gene uncharacterized LOC134479452 Neighboring gene G patch domain containing 2-like Neighboring gene estrogen-related receptor beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. C14ORF179 encoding IFT43 is mutated in Sensenbrenner syndrome. Arts HH, et al. J Med Genet, 2011 Jun. PMID 21378380
  2. Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein-coupled receptors. Hirano T, et al. Mol Biol Cell, 2017 Feb 1. PMID 27932497, Free PMC Article
  3. Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells. Broekhuis JR, et al. PLoS One, 2014. PMID 25243405, Free PMC Article
  4. TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Mukhopadhyay S, et al. Genes Dev, 2010 Oct 1. PMID 20889716, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary retrograde transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
part_of intraciliary transport particle A IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle A ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
intraflagellar transport protein 43 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134525.2 → NP_001127997.1  intraflagellar transport protein 43 homolog isoform 2

    See identical proteins and their annotated locations for NP_001127997.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I5ZM33, A6JE54
    Related
    ENSRNOP00000078860.2, ENSRNOT00000109209.2
    Conserved Domains (1) summary
    pfam15305
    Location:55 → 178
    IFT43; Intraflagellar transport protein 43

  2. NM_001399448.1 → NP_001386377.1  intraflagellar transport protein 43 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6JE52, A6JE53, D3ZY35
    Related
    ENSRNOP00000013560.5, ENSRNOT00000013560.6
    Conserved Domains (1) summary
    pfam15305
    Location:62 → 191
    IFT43; Intraflagellar transport protein 43

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    111460689..111537224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112051.2 → XP_038967979.1  intraflagellar transport protein 43 homolog isoform X4

  2. XM_039112052.2 → XP_038967980.1  intraflagellar transport protein 43 homolog isoform X5

  3. XM_039112053.2 → XP_038967981.1  intraflagellar transport protein 43 homolog isoform X6

  4. XM_017594099.3 → XP_017449588.1  intraflagellar transport protein 43 homolog isoform X1

  5. XM_017594100.3 → XP_017449589.1  intraflagellar transport protein 43 homolog isoform X3

    UniProtKB/TrEMBL
    A0A8I6G8V8, A6JE53, D3ZY35
    Related
    ENSRNOP00000082023.1, ENSRNOT00000112265.2

  6. XM_006240370.5 → XP_006240432.1  intraflagellar transport protein 43 homolog isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZRK4, A6JE53, D3ZY35
    Related
    ENSRNOP00000081023.1, ENSRNOT00000104110.2
    Conserved Domains (1) summary
    pfam15305
    Location:101 → 219
    IFT43; Intraflagellar transport protein 43

  7. XM_039112054.2 → XP_038967982.1  intraflagellar transport protein 43 homolog isoform X7

    Conserved Domains (1) summary
    pfam15305
    Location:2 → 112
    IFT43; Intraflagellar transport protein 43
Nucleotide Protein Strain
Heading Accession and Version

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