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Zdhhc22 zinc finger DHHC-type palmitoyltransferase 22 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299211, updated on 4-Jan-2025

Summary

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Official Symbol
Zdhhc22provided by RGD
Official Full Name
zinc finger DHHC-type palmitoyltransferase 22provided by RGD
Primary source
RGD:1308446
See related
EnsemblRapid:ENSRNOG00000011285 AllianceGenome:RGD:1308446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Predicted to act upstream of or within protein localization to plasma membrane and protein palmitoylation. Predicted to be located in plasma membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC22 (zinc finger DHHC-type palmitoyltransferase 22). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 52.6) See more
Orthologs
human mouse all
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Genomic context

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See Zdhhc22 in Genome Data Viewer
Location:
6q31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (112360051..112377950, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (106629090..106646996, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (111008440..111015695, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene CLOCK-interacting pacemaker Neighboring gene transfer RNA glycine (anticodon ACC) Neighboring gene transmembrane protein 63c Neighboring gene neuroglobin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. Tian L, et al. J Biol Chem, 2012 Apr 27. PMID 22399288, Free PMC Article
  2. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC22
Names
DHHC-22
membrane-associated DHHC22 zinc finger protein
putative palmitoyltransferase ZDHHC22
zinc finger DHHC domain-containing protein 22
zinc finger, DHHC domain containing 22
zinc finger, DHHC-type containing 22
NP_001034414.1
XP_038967985.1
XP_038967986.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039325.2 → NP_001034414.1  palmitoyltransferase ZDHHC22

    See identical proteins and their annotated locations for NP_001034414.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q2TGI8
    UniProtKB/TrEMBL
    A6JE75
    Related
    ENSRNOP00000054651.2, ENSRNOT00000015046.8
    Conserved Domains (1) summary
    pfam01529
    Location:91 → 218
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    112360051..112377950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112057.2 → XP_038967985.1  palmitoyltransferase ZDHHC22 isoform X1

    UniProtKB/Swiss-Prot
    Q2TGI8
    UniProtKB/TrEMBL
    A6JE75
    Conserved Domains (1) summary
    pfam01529
    Location:91 → 218
    DHHC; DHHC palmitoyltransferase

  2. XM_039112058.2 → XP_038967986.1  palmitoyltransferase ZDHHC22 isoform X1

    UniProtKB/Swiss-Prot
    Q2TGI8
    UniProtKB/TrEMBL
    A6JE75
    Conserved Domains (1) summary
    pfam01529
    Location:91 → 218
    DHHC; DHHC palmitoyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TGI8.1 GenPept UniProtKB/Swiss-Prot:Q2TGI8

Gene LinkOut

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