Golga5 golgin A5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Golga5provided by RGD
Official Full Name: golgin A5provided by RGD
Primary source: RGD:1308163
See related: EnsemblRapid:ENSRNOG00000007699 AllianceGenome:RGD:1308163
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ret-II
Summary: Enables protein-macromolecule adaptor activity and small GTPase binding activity. Involved in Golgi organization and retrograde transport, vesicle recycling within Golgi. Located in COPI-coated vesicle membrane and Golgi apparatus. Orthologous to human GOLGA5 (golgin A5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 136.8), Lung (RPKM 113.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (127377244..127405404)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (121612389..121640552)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (126350572..126378735)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab1A mediates proinsulin to insulin conversion in beta-cells by maintaining Golgi stability through interactions with golgin-84.
Title: Rab1A mediates proinsulin to insulin conversion in β-cells by maintaining Golgi stability through interactions with golgin-84.
characterization of the golgin-84-CASP tether binding to coat protein complex I (COPI) vesicles
Title: Golgin tethers define subpopulations of COPI vesicles.
Golgin-84 (Golga5) involved in generating and maintaining the architecture of the Golgi apparatus.
Title: Golgin-84 is a rab1 binding partner involved in Golgi structure.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	IDA Inferred from Direct Assay more info	PubMed
involved_in Golgi organization	IEA Inferred from Electronic Annotation more info
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi vesicle transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde transport, vesicle recycling within Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, vesicle recycling within Golgi	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in COPI-coated vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi cis cisterna	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi cisterna	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cisterna	IEA Inferred from Electronic Annotation more info
located_in Golgi cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi medial cisterna	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi trans cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in cis-Golgi network	IEA Inferred from Electronic Annotation more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: golgin subfamily A member 5

Names: golgi autoantigen, golgin subfamily a, 5; golgin-84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033065.2 → NP_001028237.2 golgin subfamily A member 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q3ZU82

UniProtKB/TrEMBL

A6JEK2, G3V6Z7

Related

ENSRNOP00000010385.3, ENSRNOT00000010385.7

Conserved Domains (2) summary

COG1196
Location:231 → 565

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09787
Location:418 → 723

Golgin_A5; Golgin subfamily A member 5